prikaz prve stranice dokumenta The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index
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Scientific paper - Original scientific paper
The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index
Leukemia, 34 (2020), 9; 2451-2459. https://doi.org/10.1038/s41375-020-0746-8
Efficace, Fabio; Cottone, Francesco; Oswald, Laura B.; Cella, David; Patriarca, Andrea; Niscola, Pasquale; Breccia, Massimo; Platzbecker, Uwe; Palumbo, Giuseppe A.; Caocci, Giovanni; Stauder, Reinhard; Ricco, Alessandra; Petranovic, Duska; Caers, Jo; Luppi, Mario; Fianchi, Luana; Frairia, Chiara; Capodanno, Isabella; Follini, Elena; Sarlo, Chiara; Fazi, Paola; Vignetti, Marco More authors...

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Efficace, F., Cottone, F., Oswald, L. B., Cella, D., Patriarca, A., Niscola, P. ... Vignetti, M. (2020). The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index. Leukemia, 34. (9), 2451-2459. doi: 10.1038/s41375-020-0746-8

Efficace, Fabio, et al. "The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index." Leukemia, vol. 34, no. 9, 2020, pp. 2451-2459. https://doi.org/10.1038/s41375-020-0746-8

Efficace, Fabio, Francesco Cottone, Laura B. Oswald, David Cella, Andrea Patriarca, Pasquale Niscola, Massimo Breccia, et al. "The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index." Leukemia 34, no. 9 (2020): 2451-2459. https://doi.org/10.1038/s41375-020-0746-8

Efficace, F., et al. (2020) 'The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index', Leukemia, 34(9), pp. 2451-2459. doi: 10.1038/s41375-020-0746-8

Efficace F, Cottone F, Oswald LB, Cella D, Patriarca A, Niscola P, and sur.. The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index. Leukemia [Internet]. 2020 February 21 [cited 2024 December 25];34(9):2451-2459. doi: 10.1038/s41375-020-0746-8

F. Efficace, et al., "The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index", Leukemia, vol. 34, no. 9, pp. 2451-2459, February 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:571101. [Accessed: 25 December 2024]

Metadata
Title (english)The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index
AuthorFabio Efficace
AuthorFrancesco Cottone
AuthorLaura B. Oswald
AuthorDavid Cella
AuthorAndrea Patriarca
AuthorPasquale Niscola
AuthorMassimo Breccia
AuthorUwe Platzbecker
AuthorGiuseppe A. Palumbo
AuthorGiovanni Caocci
AuthorReinhard Stauder
AuthorAlessandra Ricco
AuthorDuska Petranovic
AuthorJo Caers
AuthorMario Luppi
AuthorLuana Fianchi
AuthorChiara Frairia
AuthorIsabella Capodanno
AuthorElena Follini
AuthorChiara Sarlo
AuthorPaola Fazi
AuthorMarco Vignetti
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
We aimed to compare fatigue of newly diagnosed patients with myelodysplastic syndromes (MDS) with that of the general population (GP). We also investigated the ability of the IPSS and IPSS-R to capture severity of patient-reported fatigue at diagnostic workup. A sample of 927 newly diagnosed patients with MDS was consecutively enrolled in a large international observational study and all patients completed the FACIT-Fatigue questionnaire at baseline. Fatigue was compared with that of the GP (N = 1075) and a 3-point difference in mean scores was considered as clinically meaningful. Fatigue of MDS patients was on average 4.6 points below the mean of the GP (95% CI, −5.9 to −3.2, p < 0.001), reflecting clinically meaningful worse fatigue. Unlike the IPSS, the IPSS-R identified clearly distinct subgroups with regard to burden of fatigue. Mean scores differences compared with GP ranged from nonclinically relevant for very low risk (Δ = −1.8, 95% CI, −4.0 to 0.5, p = 0.119) to large clinically meaningful differences for very highrisk IPSS-R patients (Δ = −8.2, 95% CI, −10.3 to −6.2, p < 0.001). At diagnostic workup, fatigue of MDS is clinically meaningful worse than that reported by the GP. Compared with the IPSS classification, the IPSS-R provides a better stratification of patients with regard to fatigue severity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionAccepted version
Journal titleLeukemia
Numberingvol. 34, no. 9, pp. 2451-2459
p-ISSN0887-6924
e-ISSN1476-5551
DOIhttps://doi.org/10.1038/s41375-020-0746-8
URN:NBNurn:nbn:hr:184:571101
Publication2020-02-21
Document URLhttp://www.nature.com/articles/s41375-020-0746-8
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-02-18 22:22:42