prikaz prve stranice dokumenta The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index
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The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index
Leukemia, 34 (2020), 9; 2451-2459. https://doi.org/10.1038/s41375-020-0746-8
Efficace, Fabio; Cottone, Francesco; Oswald, Laura B.; Cella, David; Patriarca, Andrea; Niscola, Pasquale; Breccia, Massimo; Platzbecker, Uwe; Palumbo, Giuseppe A.; Caocci, Giovanni; Stauder, Reinhard; Ricco, Alessandra; Petranovic, Duska; Caers, Jo; Luppi, Mario; Fianchi, Luana; Frairia, Chiara; Capodanno, Isabella; Follini, Elena; Sarlo, Chiara; Fazi, Paola; Vignetti, Marco Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Efficace, F., Cottone, F., Oswald, L. B., Cella, D., Patriarca, A., Niscola, P. ... Vignetti, M. (2020). The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index. Leukemia, 34. (9), 2451-2459. doi: 10.1038/s41375-020-0746-8

Efficace, Fabio, et al. "The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index." Leukemia, vol. 34, br. 9, 2020, str. 2451-2459. https://doi.org/10.1038/s41375-020-0746-8

Efficace, Fabio, Francesco Cottone, Laura B. Oswald, David Cella, Andrea Patriarca, Pasquale Niscola, Massimo Breccia, et al. "The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index." Leukemia 34, br. 9 (2020): 2451-2459. https://doi.org/10.1038/s41375-020-0746-8

Efficace, F., et al. (2020) 'The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index', Leukemia, 34(9), str. 2451-2459. doi: 10.1038/s41375-020-0746-8

Efficace F, Cottone F, Oswald LB, Cella D, Patriarca A, Niscola P, i sur.. The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index. Leukemia [Internet]. 21.02.2020. [pristupljeno 25.12.2024.];34(9):2451-2459. doi: 10.1038/s41375-020-0746-8

F. Efficace, et al., "The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index", Leukemia, vol. 34, br. 9, str. 2451-2459, Veljača 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:571101. [Citirano: 25.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:571101
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Naslov (engleski)The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index
AutorFabio Efficace
AutorFrancesco Cottone
AutorLaura B. Oswald
AutorDavid Cella
AutorAndrea Patriarca
AutorPasquale Niscola
AutorMassimo Breccia
AutorUwe Platzbecker
AutorGiuseppe A. Palumbo
AutorGiovanni Caocci
AutorReinhard Stauder
AutorAlessandra Ricco
AutorDuska Petranovic
AutorJo Caers
AutorMario Luppi
AutorLuana Fianchi
AutorChiara Frairia
AutorIsabella Capodanno
AutorElena Follini
AutorChiara Sarlo
AutorPaola Fazi
AutorMarco Vignetti
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
We aimed to compare fatigue of newly diagnosed patients with myelodysplastic syndromes (MDS) with that of the general population (GP). We also investigated the ability of the IPSS and IPSS-R to capture severity of patient-reported fatigue at diagnostic workup. A sample of 927 newly diagnosed patients with MDS was consecutively enrolled in a large international observational study and all patients completed the FACIT-Fatigue questionnaire at baseline. Fatigue was compared with that of the GP (N = 1075) and a 3-point difference in mean scores was considered as clinically meaningful. Fatigue of MDS patients was on average 4.6 points below the mean of the GP (95% CI, −5.9 to −3.2, p < 0.001), reflecting clinically meaningful worse fatigue. Unlike the IPSS, the IPSS-R identified clearly distinct subgroups with regard to burden of fatigue. Mean scores differences compared with GP ranged from nonclinically relevant for very low risk (Δ = −1.8, 95% CI, −4.0 to 0.5, p = 0.119) to large clinically meaningful differences for very highrisk IPSS-R patients (Δ = −8.2, 95% CI, −10.3 to −6.2, p < 0.001). At diagnostic workup, fatigue of MDS is clinically meaningful worse than that reported by the GP. Compared with the IPSS classification, the IPSS-R provides a better stratification of patients with regard to fatigue severity.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaLeukemia
Brojčani podacivol. 34, br. 9, str. 2451-2459
p-ISSN0887-6924
e-ISSN1476-5551
DOIhttps://doi.org/10.1038/s41375-020-0746-8
URN:NBNurn:nbn:hr:184:571101
Datum objave publikacije2020-02-21
URL dokumentahttp://www.nature.com/articles/s41375-020-0746-8
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-02-18 22:22:42