prikaz prve stranice dokumenta Association between PLA2G6 gene polymorphism for calcium-independent phospholipase A2 and nicotine dependence among males with schizophrenia
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Scientific paper - Original scientific paper
Association between PLA2G6 gene polymorphism for calcium-independent phospholipase A2 and nicotine dependence among males with schizophrenia
Prostaglandins, Leukotrienes and Essential Fatty Acids, 148 (2019); 9-15. https://doi.org/10.1016/j.plefa.2019.07.005
Nadalin, Sergej; Rebić, Jelena; Šendula Jengić, Vesna; Peitl, Vjekoslav; Karlović, Dalibor; Buretić-Tomljanović, Alena

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Nadalin, S., Rebić, J., Šendula Jengić, V., Peitl, V., Karlović, D. & Buretić Tomljanović, A. (2019). Association between PLA2G6 gene polymorphism for calcium-independent phospholipase A2 and nicotine dependence among males with schizophrenia. Prostaglandins, Leukotrienes and Essential Fatty Acids, 148., 9-15. doi: 10.1016/j.plefa.2019.07.005

Nadalin, Sergej, et al. "Association between PLA2G6 gene polymorphism for calcium-independent phospholipase A2 and nicotine dependence among males with schizophrenia." Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 148, 2019, pp. 9-15. https://doi.org/10.1016/j.plefa.2019.07.005

Nadalin, Sergej, Jelena Rebić, Vesna Šendula Jengić, Vjekoslav Peitl, Dalibor Karlović and Alena Buretić Tomljanović. "Association between PLA2G6 gene polymorphism for calcium-independent phospholipase A2 and nicotine dependence among males with schizophrenia." Prostaglandins, Leukotrienes and Essential Fatty Acids 148 (2019): 9-15. https://doi.org/10.1016/j.plefa.2019.07.005

Nadalin, S., et al. (2019) 'Association between PLA2G6 gene polymorphism for calcium-independent phospholipase A2 and nicotine dependence among males with schizophrenia', Prostaglandins, Leukotrienes and Essential Fatty Acids, 148, pp. 9-15. doi: 10.1016/j.plefa.2019.07.005

Nadalin S, Rebić J, Šendula Jengić V, Peitl V, Karlović D, Buretić Tomljanović A. Association between PLA2G6 gene polymorphism for calcium-independent phospholipase A2 and nicotine dependence among males with schizophrenia. Prostaglandins, Leukotrienes and Essential Fatty Acids [Internet]. 2019 [cited 2024 April 17];148:9-15. doi: 10.1016/j.plefa.2019.07.005

S. Nadalin, J. Rebić, V. Šendula Jengić, V. Peitl, D. Karlović and A. Buretić Tomljanović, "Association between PLA2G6 gene polymorphism for calcium-independent phospholipase A2 and nicotine dependence among males with schizophrenia", Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 148, pp. 9-15, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:605890. [Accessed: 17 April 2024]

Metadata
Title (english)Association between PLA2G6 gene polymorphism for calcium-independent phospholipase A2 and nicotine dependence among males with schizophrenia
AuthorSergej Nadalin
AuthorJelena Rebić
AuthorVesna Šendula Jengić
AuthorVjekoslav Peitl
MBZ: 361852
AuthorDalibor Karlović
MBZ: 251183
AuthorAlena Buretić-Tomljanović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
We investigated the relationship between the rs10798059 (BanI) and rs4375 polymorphisms in the phospholipase A2 (PLA2)G4A and PLA2G6 genes and the risk of nicotine dependence in 263 Croatian patients with schizophrenia. We also examined whether interactions between these polymorphisms and smoking contributed to schizophrenia onset and Positive and Negative Syndrome Scale (PANSS) psychopathology. We found no significant differences in the distribution of PLA2G4A genotypes and alleles according to smoking status, and no effect of the PLA2G4A genotype-smoking interaction on disease onset or PANSS. The PLA2G6-TT homozygous genotype was significantly overrepresented in male smokers compared to nonsmokers (34.7% vs. 17.1%, p < 0.05). These patients had similar to 2.6-fold higher risk of becoming smokers than males with heterozygous PLA2G6-CT and homozygous PLA2G6-CC genotypes. In addition, male smokers without the PLA2G6-C allele (PLA2G6-TT homozygous) experienced earlier onset than nonsmoking homozygous PLA2G6-TT males. Thus, the PLA2G6 polymorphism affected the risk of nicotine dependence in male patients and the PLA2G6 genotype smoking interaction was linked to the age of disease onset.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleProstaglandins, Leukotrienes and Essential Fatty Acids
Numberingvol. 148, pp. 9-15
p-ISSN0952-3278
DOIhttps://doi.org/10.1016/j.plefa.2019.07.005
URN:NBNurn:nbn:hr:184:605890
Publication2019
Document URLhttp://bib.irb.hr/1058720
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-02-08 12:26:51