prikaz prve stranice dokumenta Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis
No public access
Scientific paper - Original scientific paper
Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis
Neurotoxicology, 57 (2016); 1-12. https://doi.org/10.1016/j.neuro.2016.08.014
Ćurko-Cofek, Božena; Grubić Kezele, Tanja; Marinić, Jelena; Tota, Marin; Starčević Čizmarević, Nada; Milin, Čedomila; Ristić, Smiljana; Radošević-Stašić, Biserka; Barac-Latas, Vesna

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Ćurko Cofek, B., Grubić Kezele, T., Marinić, J., Tota, M., Starčević Čizmarević, N., Milin, Č. ... Barac Latas, V. (2016). Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis. Neurotoxicology, 57., 1-12. doi: 10.1016/j.neuro.2016.08.014

Ćurko Cofek, Božena, et al. "Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis." Neurotoxicology, vol. 57, 2016, pp. 1-12. https://doi.org/10.1016/j.neuro.2016.08.014

Ćurko Cofek, Božena, Tanja Grubić Kezele, Jelena Marinić, Marin Tota, Nada Starčević Čizmarević, Čedomila Milin, Smiljana Ristić, Biserka Radošević Stašić and Vesna Barac Latas. "Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis." Neurotoxicology 57 (2016): 1-12. https://doi.org/10.1016/j.neuro.2016.08.014

Ćurko Cofek, B., et al. (2016) 'Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis', Neurotoxicology, 57, pp. 1-12. doi: 10.1016/j.neuro.2016.08.014

Ćurko Cofek B, Grubić Kezele T, Marinić J, Tota M, Starčević Čizmarević N, Milin Č, and sur.. Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis. Neurotoxicology [Internet]. 2016 [cited 2024 November 08];57:1-12. doi: 10.1016/j.neuro.2016.08.014

B. Ćurko Cofek, et al., "Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis", Neurotoxicology, vol. 57, pp. 1-12, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:422039. [Accessed: 08 November 2024]

Metadata
Title (english)Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis
AuthorBožena Ćurko-Cofek
AuthorTanja Grubić Kezele
AuthorJelena Marinić
AuthorMarin Tota
AuthorNada Starčević Čizmarević
AuthorČedomila Milin
AuthorSmiljana Ristić
MBZ: 142283
AuthorBiserka Radošević-Stašić
AuthorVesna Barac-Latas
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
To analyze iron- and gender-dependent mechanisms possibly involved in pathogenesis of multiple sclerosis (MS) in this study we evaluated the effects of iron overload (IO) on iron status and lipid peroxidation processes (LPO) in tissues of female and male DA rats during chronic relapsing experimental autoimmune encephalomyelitis, a well- established MS animal model. Rats were treated by iron sucrose (75 mg/kg bw/day) or with saline solution during two weeks before the sensitization with bovine brain homogenate in complete Freund's adjuvant. Clinical signs of EAE were monitored during 29 days. Serum and tissues of CNS and liver were sampled before immunization and at day 13th post immunization (during acute phase of EAE). The determination of ferritin, iron, malondialdehyde (MDA) and 4- hydroxynonenal (4-HNE) and evaluation of histopathology were performed by ELISA, ICP spectrometry and immunohistochemistry. Results showed that IO in female EAE rats accelerated the onset of disease. In contrast, in male rats it accelerated the progression of disease and increased the mortality rate. During acute phase of EAE female IO rats sequestered more Fe in the liver, spinal cord and in the brain and produced more ferritin than male EAE rats. Male rats, however, reacted on IO by higher production of MDA or 4-HNE in the neural tissues and showed greater signs of plaque formation and gliosis in spinal cord. The data point to sexual dimorphism in mechanisms that regulate peripheral and brain iron homeostasis and imply that men and women during MS might be differentially vulnerable to exogenous iron overload.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNeurotoxicology
Numberingvol. 57, pp. 1-12
p-ISSN0161-813X
DOIhttps://doi.org/10.1016/j.neuro.2016.08.014
URN:NBNurn:nbn:hr:184:422039
Publication2016
Document URLhttp://bib.irb.hr/822455
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-02-10 13:05:55