prikaz prve stranice dokumenta Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis
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Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis
Neurotoxicology, 57 (2016); 1-12. https://doi.org/10.1016/j.neuro.2016.08.014
Ćurko-Cofek, Božena; Grubić Kezele, Tanja; Marinić, Jelena; Tota, Marin; Starčević Čizmarević, Nada; Milin, Čedomila; Ristić, Smiljana; Radošević-Stašić, Biserka; Barac-Latas, Vesna

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Ćurko Cofek, B., Grubić Kezele, T., Marinić, J., Tota, M., Starčević Čizmarević, N., Milin, Č. ... Barac Latas, V. (2016). Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis. Neurotoxicology, 57., 1-12. doi: 10.1016/j.neuro.2016.08.014

Ćurko Cofek, Božena, et al. "Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis." Neurotoxicology, vol. 57, 2016, str. 1-12. https://doi.org/10.1016/j.neuro.2016.08.014

Ćurko Cofek, Božena, Tanja Grubić Kezele, Jelena Marinić, Marin Tota, Nada Starčević Čizmarević, Čedomila Milin, Smiljana Ristić, Biserka Radošević Stašić i Vesna Barac Latas. "Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis." Neurotoxicology 57 (2016): 1-12. https://doi.org/10.1016/j.neuro.2016.08.014

Ćurko Cofek, B., et al. (2016) 'Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis', Neurotoxicology, 57, str. 1-12. doi: 10.1016/j.neuro.2016.08.014

Ćurko Cofek B, Grubić Kezele T, Marinić J, Tota M, Starčević Čizmarević N, Milin Č, i sur.. Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis. Neurotoxicology [Internet]. 2016. [pristupljeno 26.04.2024.];57:1-12. doi: 10.1016/j.neuro.2016.08.014

B. Ćurko Cofek, et al., "Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis", Neurotoxicology, vol. 57, str. 1-12, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:422039. [Citirano: 26.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:422039
Podaci o radu
Naslov (engleski)Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis
AutorBožena Ćurko-Cofek
AutorTanja Grubić Kezele
AutorJelena Marinić
AutorMarin Tota
AutorNada Starčević Čizmarević
AutorČedomila Milin
AutorSmiljana Ristić
MBZ: 142283
AutorBiserka Radošević-Stašić
AutorVesna Barac-Latas
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
To analyze iron- and gender-dependent mechanisms possibly involved in pathogenesis of multiple sclerosis (MS) in this study we evaluated the effects of iron overload (IO) on iron status and lipid peroxidation processes (LPO) in tissues of female and male DA rats during chronic relapsing experimental autoimmune encephalomyelitis, a well- established MS animal model. Rats were treated by iron sucrose (75 mg/kg bw/day) or with saline solution during two weeks before the sensitization with bovine brain homogenate in complete Freund's adjuvant. Clinical signs of EAE were monitored during 29 days. Serum and tissues of CNS and liver were sampled before immunization and at day 13th post immunization (during acute phase of EAE). The determination of ferritin, iron, malondialdehyde (MDA) and 4- hydroxynonenal (4-HNE) and evaluation of histopathology were performed by ELISA, ICP spectrometry and immunohistochemistry. Results showed that IO in female EAE rats accelerated the onset of disease. In contrast, in male rats it accelerated the progression of disease and increased the mortality rate. During acute phase of EAE female IO rats sequestered more Fe in the liver, spinal cord and in the brain and produced more ferritin than male EAE rats. Male rats, however, reacted on IO by higher production of MDA or 4-HNE in the neural tissues and showed greater signs of plaque formation and gliosis in spinal cord. The data point to sexual dimorphism in mechanisms that regulate peripheral and brain iron homeostasis and imply that men and women during MS might be differentially vulnerable to exogenous iron overload.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNeurotoxicology
Brojčani podacivol. 57, str. 1-12
p-ISSN0161-813X
DOIhttps://doi.org/10.1016/j.neuro.2016.08.014
URN:NBNurn:nbn:hr:184:422039
Datum objave publikacije2016
URL dokumentahttp://bib.irb.hr/822455
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-10 13:05:55