prikaz prve stranice dokumenta Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells
  Download
PDF 1.52 MB
Scientific paper - Original scientific paper
Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells
Proceedings of the National Academy of Sciences of the United States of America, 117 (2020), 23; 12961-12968. https://doi.org/10.1073/pnas.1914667117
Chaudhry, MZ; Casalegno-Garduno, R; Sitnik, KM; Kasmapour, B; Pulm, A-K; Brizić, Ilija; Eiz-Vesper, B; Moosmann, A; Jonjić, Stipan; Mocarski, ES; Čičin-Šain, Luka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Chaudhry, M., Casalegno Garduno, R., Sitnik, K., Kasmapour, B., Pulm, A. K., Brizić, I. ... Čičin Šain, L. (2020). Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells. Proceedings of the National Academy of Sciences of the United States of America, 117. (23), 12961-12968. doi: 10.1073/pnas.1914667117

Chaudhry, MZ, et al. "Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells." Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 23, 2020, pp. 12961-12968. https://doi.org/10.1073/pnas.1914667117

Chaudhry, MZ, R Casalegno Garduno, KM Sitnik, B Kasmapour, A K Pulm, Ilija Brizić, B Eiz Vesper, et al. "Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells." Proceedings of the National Academy of Sciences of the United States of America 117, no. 23 (2020): 12961-12968. https://doi.org/10.1073/pnas.1914667117

Chaudhry, M., et al. (2020) 'Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells', Proceedings of the National Academy of Sciences of the United States of America, 117(23), pp. 12961-12968. doi: 10.1073/pnas.1914667117

Chaudhry M, Casalegno Garduno R, Sitnik K, Kasmapour B, Pulm AK, Brizić I, and sur.. Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2020 [cited 2024 November 26];117(23):12961-12968. doi: 10.1073/pnas.1914667117

M. Chaudhry, et al., "Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells", Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 23, pp. 12961-12968, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:052473. [Accessed: 26 November 2024]

Metadata
Title (english)Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells
AuthorMZ Chaudhry
AuthorR Casalegno-Garduno
AuthorKM Sitnik
AuthorB Kasmapour
AuthorA-K Pulm
AuthorIlija Brizić
AuthorB Eiz-Vesper
AuthorA Moosmann
AuthorStipan Jonjić
AuthorES Mocarski
AuthorLuka Čičin-Šain
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Viral immune evasion is currently understood to focus on deflecting CD8 T cell recognition of infected cells by disrupting antigen presentation pathways. We evaluated viral interference with the ultimate step in cytotoxic T cell function, the death of infected cells. The viral inhibitor of caspase- 8 activation (vICA) conserved in human cytomegalovirus (HCMV) and murine CMV (MCMV) prevents the activation of caspase-8 and proapoptotic signaling. We demonstrate the key role of vICA from either virus, in deflecting antigen-specific CD8 T cell-killing of infected cells. vICA-deficient mutants, lacking either UL36 or M36, exhibit greater susceptibility to CD8 T cell control than mutants lacking the set of immunoevasins known to disrupt antigen presentation via MHC class I. This difference is evident during infection in the natural mouse host infected with MCMV, in settings where virus-specific CD8 T cells are adoptively transferred. Finally, we identify the molecular mechanism through which vICA acts, demonstrating the central contribution of caspase-8 signaling at a point of convergence of death receptor-induced apoptosis and perforin/granzyme-dependent cytotoxicity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleProceedings of the National Academy of Sciences of the United States of America
Numberingvol. 117, no. 23, pp. 12961-12968
p-ISSN0027-8424
DOIhttps://doi.org/10.1073/pnas.1914667117
URN:NBNurn:nbn:hr:184:052473
Publication2020
Document URLhttp://bib.irb.hr/1105797
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-02-15 11:40:58