prikaz prve stranice dokumenta Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells
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Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells
Proceedings of the National Academy of Sciences of the United States of America, 117 (2020), 23; 12961-12968. https://doi.org/10.1073/pnas.1914667117
Chaudhry, MZ; Casalegno-Garduno, R; Sitnik, KM; Kasmapour, B; Pulm, A-K; Brizić, Ilija; Eiz-Vesper, B; Moosmann, A; Jonjić, Stipan; Mocarski, ES; Čičin-Šain, Luka

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Chaudhry, M., Casalegno Garduno, R., Sitnik, K., Kasmapour, B., Pulm, A. K., Brizić, I. ... Čičin Šain, L. (2020). Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells. Proceedings of the National Academy of Sciences of the United States of America, 117. (23), 12961-12968. doi: 10.1073/pnas.1914667117

Chaudhry, MZ, et al. "Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells." Proceedings of the National Academy of Sciences of the United States of America, vol. 117, br. 23, 2020, str. 12961-12968. https://doi.org/10.1073/pnas.1914667117

Chaudhry, MZ, R Casalegno Garduno, KM Sitnik, B Kasmapour, A K Pulm, Ilija Brizić, B Eiz Vesper, et al. "Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells." Proceedings of the National Academy of Sciences of the United States of America 117, br. 23 (2020): 12961-12968. https://doi.org/10.1073/pnas.1914667117

Chaudhry, M., et al. (2020) 'Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells', Proceedings of the National Academy of Sciences of the United States of America, 117(23), str. 12961-12968. doi: 10.1073/pnas.1914667117

Chaudhry M, Casalegno Garduno R, Sitnik K, Kasmapour B, Pulm AK, Brizić I, i sur.. Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2020. [pristupljeno 15.05.2024.];117(23):12961-12968. doi: 10.1073/pnas.1914667117

M. Chaudhry, et al., "Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells", Proceedings of the National Academy of Sciences of the United States of America, vol. 117, br. 23, str. 12961-12968, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:052473. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:052473
Podaci o radu
Naslov (engleski)Cytomegalovirus Inhibition of Extrinsic Apoptosis Determines Fitness and Resistance to Cytotoxic CD8 T Cells
AutorMZ Chaudhry
AutorR Casalegno-Garduno
AutorKM Sitnik
AutorB Kasmapour
AutorA-K Pulm
AutorIlija Brizić
AutorB Eiz-Vesper
AutorA Moosmann
AutorStipan Jonjić
AutorES Mocarski
AutorLuka Čičin-Šain
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Viral immune evasion is currently understood to focus on deflecting CD8 T cell recognition of infected cells by disrupting antigen presentation pathways. We evaluated viral interference with the ultimate step in cytotoxic T cell function, the death of infected cells. The viral inhibitor of caspase- 8 activation (vICA) conserved in human cytomegalovirus (HCMV) and murine CMV (MCMV) prevents the activation of caspase-8 and proapoptotic signaling. We demonstrate the key role of vICA from either virus, in deflecting antigen-specific CD8 T cell-killing of infected cells. vICA-deficient mutants, lacking either UL36 or M36, exhibit greater susceptibility to CD8 T cell control than mutants lacking the set of immunoevasins known to disrupt antigen presentation via MHC class I. This difference is evident during infection in the natural mouse host infected with MCMV, in settings where virus-specific CD8 T cells are adoptively transferred. Finally, we identify the molecular mechanism through which vICA acts, demonstrating the central contribution of caspase-8 signaling at a point of convergence of death receptor-induced apoptosis and perforin/granzyme-dependent cytotoxicity.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaProceedings of the National Academy of Sciences of the United States of America
Brojčani podacivol. 117, br. 23, str. 12961-12968
p-ISSN0027-8424
DOIhttps://doi.org/10.1073/pnas.1914667117
URN:NBNurn:nbn:hr:184:052473
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1105797
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-02-15 11:40:58