prikaz prve stranice dokumenta Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis
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Scientific paper - Original scientific paper
Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis
Medical hypotheses, 87 (2016); 66-68. https://doi.org/10.1016/j.mehy.2015.12.004
Vičić, Marijana; Peternel, Sandra; Simonić, Edita; Sotošek- Tokmadžić, Vlatka; Massari, Dražen; Brajac, Ines; Kaštelan, Marija; Prpić-Massari, Larisa

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Vičić, M., Peternel, S., Simonić, E., Sotošek Tokmadžić, V., Massari, D., Brajac, I. ... Prpić Massari, L. (2016). Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis. Medical hypotheses, 87., 66-68. doi: 10.1016/j.mehy.2015.12.004

Vičić, Marijana, et al. "Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis." Medical hypotheses, vol. 87, 2016, pp. 66-68. https://doi.org/10.1016/j.mehy.2015.12.004

Vičić, Marijana, Sandra Peternel, Edita Simonić, Vlatka Sotošek Tokmadžić, Dražen Massari, Ines Brajac, Marija Kaštelan and Larisa Prpić Massari. "Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis." Medical hypotheses 87 (2016): 66-68. https://doi.org/10.1016/j.mehy.2015.12.004

Vičić, M., et al. (2016) 'Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis', Medical hypotheses, 87, pp. 66-68. doi: 10.1016/j.mehy.2015.12.004

Vičić M, Peternel S, Simonić E, Sotošek Tokmadžić V, Massari D, Brajac I, and sur.. Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis. Medical hypotheses [Internet]. 2016 [cited 2024 December 27];87:66-68. doi: 10.1016/j.mehy.2015.12.004

M. Vičić, et al., "Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis", Medical hypotheses, vol. 87, pp. 66-68, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:691634. [Accessed: 27 December 2024]

Metadata
Title (english)Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis
AuthorMarijana Vičić
AuthorSandra Peternel
AuthorEdita Simonić
AuthorVlatka Sotošek- Tokmadžić
AuthorDražen Massari
MBZ: 257913
AuthorInes Brajac
AuthorMarija Kaštelan
MBZ: 188650
AuthorLarisa Prpić-Massari
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Psoriasis is a chronic papulosquamous skin disease, histologically characterized by epidermal hyperproliferation and dermal infiltration of inflammatory cells. The majority of T lymphocytes infiltrating dermis are CD4+ T lymphocytes secreting type 1 and type 17 cytokines. These cytokines are responsible for triggering keratinocyte proliferation as well as chemokine secretion and subsequent migration of other inflammatory cells in the skin. Contrarily, lymphocytes that accumulate in epidermis are mainly CD8+ T lymphocytes. According to the recent findings, these cells can also secrete type 1 and type 17 cytokines. However, it is demonstrated so far that epidermal CD8+ T lymphocytes contain higher amounts of cytolytic molecules, such as perforin, granzyme B and granulysin whose role in psoriasis pathogenesis is still unknown. Therefore, in this article we hypothesize the active involvement of cell mediated cytotoxicity in killing the proliferating keratinocytes as a mechanism of potential self-defense and possible brake in psoriatic plaque formation, maintaining skin homeostasis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedical hypotheses
Numberingvol. 87, pp. 66-68
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2015.12.004
URN:NBNurn:nbn:hr:184:691634
Publication2016
Document URLhttp://bib.irb.hr/806334
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-02-15 17:04:10