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Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis
Medical hypotheses, 87 (2016); 66-68. https://doi.org/10.1016/j.mehy.2015.12.004
Vičić, Marijana; Peternel, Sandra; Simonić, Edita; Sotošek- Tokmadžić, Vlatka; Massari, Dražen; Brajac, Ines; Kaštelan, Marija; Prpić-Massari, Larisa

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Vičić, M., Peternel, S., Simonić, E., Sotošek Tokmadžić, V., Massari, D., Brajac, I. ... Prpić Massari, L. (2016). Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis. Medical hypotheses, 87., 66-68. doi: 10.1016/j.mehy.2015.12.004

Vičić, Marijana, et al. "Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis." Medical hypotheses, vol. 87, 2016, str. 66-68. https://doi.org/10.1016/j.mehy.2015.12.004

Vičić, Marijana, Sandra Peternel, Edita Simonić, Vlatka Sotošek Tokmadžić, Dražen Massari, Ines Brajac, Marija Kaštelan i Larisa Prpić Massari. "Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis." Medical hypotheses 87 (2016): 66-68. https://doi.org/10.1016/j.mehy.2015.12.004

Vičić, M., et al. (2016) 'Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis', Medical hypotheses, 87, str. 66-68. doi: 10.1016/j.mehy.2015.12.004

Vičić M, Peternel S, Simonić E, Sotošek Tokmadžić V, Massari D, Brajac I, i sur.. Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis. Medical hypotheses [Internet]. 2016. [pristupljeno 01.05.2024.];87:66-68. doi: 10.1016/j.mehy.2015.12.004

M. Vičić, et al., "Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis", Medical hypotheses, vol. 87, str. 66-68, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:691634. [Citirano: 01.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:691634
Podaci o radu
Naslov (engleski)Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis
AutorMarijana Vičić
AutorSandra Peternel
AutorEdita Simonić
AutorVlatka Sotošek- Tokmadžić
AutorDražen Massari
MBZ: 257913
AutorInes Brajac
AutorMarija Kaštelan
MBZ: 188650
AutorLarisa Prpić-Massari
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za dermatovenerologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
Psoriasis is a chronic papulosquamous skin disease, histologically characterized by epidermal hyperproliferation and dermal infiltration of inflammatory cells. The majority of T lymphocytes infiltrating dermis are CD4+ T lymphocytes secreting type 1 and type 17 cytokines. These cytokines are responsible for triggering keratinocyte proliferation as well as chemokine secretion and subsequent migration of other inflammatory cells in the skin. Contrarily, lymphocytes that accumulate in epidermis are mainly CD8+ T lymphocytes. According to the recent findings, these cells can also secrete type 1 and type 17 cytokines. However, it is demonstrated so far that epidermal CD8+ T lymphocytes contain higher amounts of cytolytic molecules, such as perforin, granzyme B and granulysin whose role in psoriasis pathogenesis is still unknown. Therefore, in this article we hypothesize the active involvement of cell mediated cytotoxicity in killing the proliferating keratinocytes as a mechanism of potential self-defense and possible brake in psoriatic plaque formation, maintaining skin homeostasis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical hypotheses
Brojčani podacivol. 87, str. 66-68
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2015.12.004
URN:NBNurn:nbn:hr:184:691634
Datum objave publikacije2016
URL dokumentahttp://bib.irb.hr/806334
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-15 17:04:10