prikaz prve stranice dokumenta The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score
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Scientific paper - Original scientific paper
The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score
Journal of biological regulators & homeostatic agents, 33 (2019), 1; 29-38. urn:nbn:hr:184:342419
Oštrić, Marin; Kukuljan, Melita; Markić, Dean; Gršković, Antun; Ivančić, Aldo; Bobinac, Dragica; Španjol, Josip; Maroević, Jan; Šoša, Ivan; Ćelić, Tanja

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Oštrić, M., Kukuljan, M., Markić, D., Gršković, A., Ivančić, A., Bobinac, D. ... Ćelić, T. (2019). The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score. Journal of biological regulators & homeostatic agents, 33. (1), 29-38. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:342419

Oštrić, Marin, et al. "The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score." Journal of biological regulators & homeostatic agents, vol. 33, no. 1, 2019, pp. 29-38. https://urn.nsk.hr/urn:nbn:hr:184:342419

Oštrić, Marin, Melita Kukuljan, Dean Markić, Antun Gršković, Aldo Ivančić, Dragica Bobinac, Josip Španjol, Jan Maroević, Ivan Šoša and Tanja Ćelić. "The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score." Journal of biological regulators & homeostatic agents 33, no. 1 (2019): 29-38. https://urn.nsk.hr/urn:nbn:hr:184:342419

Oštrić, M., et al. (2019) 'The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score', Journal of biological regulators & homeostatic agents, 33(1), pp. 29-38. Available at: https://urn.nsk.hr/urn:nbn:hr:184:342419 (Accessed 29 April 2024)

Oštrić M, Kukuljan M, Markić D, Gršković A, Ivančić A, Bobinac D, and sur.. The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score. Journal of biological regulators & homeostatic agents [Internet]. 2019 [cited 2024 April 29];33(1):29-38. Available at: https://urn.nsk.hr/urn:nbn:hr:184:342419

M. Oštrić, et al., "The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score", Journal of biological regulators & homeostatic agents, vol. 33, no. 1, pp. 29-38, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:342419. [Accessed: 29 April 2024]

Metadata
Title (english)The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score
AuthorMarin Oštrić
AuthorMelita Kukuljan
AuthorDean Markić
AuthorAntun Gršković
AuthorAldo Ivančić
AuthorDragica Bobinac
AuthorJosip Španjol
AuthorJan Maroević
AuthorIvan Šoša
AuthorTanja Ćelić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Forensic Medicine and Criminalistics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
Since vascular calcification is considered process regulated similar as bone tissue mineralization, we investigated the participation of bone formation proteins. We analyzed correlation of serum circulating bone markers, osteoprotegerin (OPG) and receptor activator of nuclear factor ĸB ligand (RANKL) in chronic kidney disease (CKD) patients, to coronary artery calcification score. Aside of that we consifrtrf thr effect of inorganic phosphate on pro- and anti- calcifying tissue factors. We confirmed that circulating OPG is independent calcium score predictor with its high serum concentration speaking in favor of high coronary artery calcification. In tissue samples of non-diseased human renal arteries, the expression of OPG and receptor activator of nuclear factor ĸB (RANK) was positive, while expression of RANKL was absent. In atherosclerotic specimens and arteries with medial calcification most upregulated was expression of bone morphogenetic proteins, BMP- 2 and BMP-7, as well as expression of RANK and RANKL. In the diseased arteries OPG expression was present, only in areas where bone structures were formed. In atherosclerotic and medial calcification arteries loss of alpha- smooth muscle actin (α-SMA) expression was observed. These data suggest a possible regulatory role of examined proteins, especially OPG and RANKL in vascular calcification, as well as their possible clinical significance as circulating predictors of vascular calcification.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of biological regulators & homeostatic agents
Numberingvol. 33, no. 1, pp. 29-38
p-ISSN0393-974X
URN:NBNurn:nbn:hr:184:342419
Publication2019
Document URLhttp://bib.irb.hr/969885
Type of resourceText
Access conditionsClosed access
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Created on2022-02-21 11:26:28