prikaz prve stranice dokumenta The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score
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The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score
Journal of biological regulators & homeostatic agents, 33 (2019), 1; 29-38. urn:nbn:hr:184:342419
Oštrić, Marin; Kukuljan, Melita; Markić, Dean; Gršković, Antun; Ivančić, Aldo; Bobinac, Dragica; Španjol, Josip; Maroević, Jan; Šoša, Ivan; Ćelić, Tanja

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Oštrić, M., Kukuljan, M., Markić, D., Gršković, A., Ivančić, A., Bobinac, D. ... Ćelić, T. (2019). The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score. Journal of biological regulators & homeostatic agents, 33. (1), 29-38. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:342419

Oštrić, Marin, et al. "The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score." Journal of biological regulators & homeostatic agents, vol. 33, br. 1, 2019, str. 29-38. https://urn.nsk.hr/urn:nbn:hr:184:342419

Oštrić, Marin, Melita Kukuljan, Dean Markić, Antun Gršković, Aldo Ivančić, Dragica Bobinac, Josip Španjol, Jan Maroević, Ivan Šoša i Tanja Ćelić. "The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score." Journal of biological regulators & homeostatic agents 33, br. 1 (2019): 29-38. https://urn.nsk.hr/urn:nbn:hr:184:342419

Oštrić, M., et al. (2019) 'The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score', Journal of biological regulators & homeostatic agents, 33(1), str. 29-38. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:342419 (Datum pristupa: 08.05.2024.)

Oštrić M, Kukuljan M, Markić D, Gršković A, Ivančić A, Bobinac D, i sur.. The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score. Journal of biological regulators & homeostatic agents [Internet]. 2019. [pristupljeno 08.05.2024.];33(1):29-38. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:342419

M. Oštrić, et al., "The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score", Journal of biological regulators & homeostatic agents, vol. 33, br. 1, str. 29-38, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:342419. [Citirano: 08.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:342419
Podaci o radu
Naslov (engleski)The Expression of Bone-Related Proteins in Vascular Calcification and its Serum Correlations with Coronary Artery Calcification Score
AutorMarin Oštrić
AutorMelita Kukuljan
AutorDean Markić
AutorAntun Gršković
AutorAldo Ivančić
AutorDragica Bobinac
AutorJosip Španjol
AutorJan Maroević
AutorIvan Šoša
AutorTanja Ćelić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za sudsku medicinu i kriminalistiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za urologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Urologija
Sažetak (engleski)
Since vascular calcification is considered process regulated similar as bone tissue mineralization, we investigated the participation of bone formation proteins. We analyzed correlation of serum circulating bone markers, osteoprotegerin (OPG) and receptor activator of nuclear factor ĸB ligand (RANKL) in chronic kidney disease (CKD) patients, to coronary artery calcification score. Aside of that we consifrtrf thr effect of inorganic phosphate on pro- and anti- calcifying tissue factors. We confirmed that circulating OPG is independent calcium score predictor with its high serum concentration speaking in favor of high coronary artery calcification. In tissue samples of non-diseased human renal arteries, the expression of OPG and receptor activator of nuclear factor ĸB (RANK) was positive, while expression of RANKL was absent. In atherosclerotic specimens and arteries with medial calcification most upregulated was expression of bone morphogenetic proteins, BMP- 2 and BMP-7, as well as expression of RANK and RANKL. In the diseased arteries OPG expression was present, only in areas where bone structures were formed. In atherosclerotic and medial calcification arteries loss of alpha- smooth muscle actin (α-SMA) expression was observed. These data suggest a possible regulatory role of examined proteins, especially OPG and RANKL in vascular calcification, as well as their possible clinical significance as circulating predictors of vascular calcification.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of biological regulators & homeostatic agents
Brojčani podacivol. 33, br. 1, str. 29-38
p-ISSN0393-974X
URN:NBNurn:nbn:hr:184:342419
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/969885
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-21 11:26:28