prikaz prve stranice dokumenta "Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"
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Scientific paper - Original scientific paper
"Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"
Journal of cutaneous pathology, 47 (2020), 2; 139-145. urn:nbn:hr:184:519112
Zamolo, Gordana; Grahovac, Maja; Žauhar, Gordana; Vučinić, Damir; Kovač, Leo; Brajenić, Nika; Grahovac, Blaženka

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Cite this document

Zamolo, G., Grahovac, M., Žauhar, G., Vučinić, D., Kovač, L., Brajenić, N. & Grahovac, B. (2020). "Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma". Journal of cutaneous pathology, 47. (2), 139-145. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:519112

Zamolo, Gordana, et al. ""Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"." Journal of cutaneous pathology, vol. 47, no. 2, 2020, pp. 139-145. https://urn.nsk.hr/urn:nbn:hr:184:519112

Zamolo, Gordana, Maja Grahovac, Gordana Žauhar, Damir Vučinić, Leo Kovač, Nika Brajenić and Blaženka Grahovac. ""Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"." Journal of cutaneous pathology 47, no. 2 (2020): 139-145. https://urn.nsk.hr/urn:nbn:hr:184:519112

Zamolo, G., et al. (2020) '"Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"', Journal of cutaneous pathology, 47(2), pp. 139-145. Available at: https://urn.nsk.hr/urn:nbn:hr:184:519112 (Accessed 10 May 2024)

Zamolo G, Grahovac M, Žauhar G, Vučinić D, Kovač L, Brajenić N, and sur.. "Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma". Journal of cutaneous pathology [Internet]. 2020 [cited 2024 May 10];47(2):139-145. Available at: https://urn.nsk.hr/urn:nbn:hr:184:519112

G. Zamolo, et al., ""Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"", Journal of cutaneous pathology, vol. 47, no. 2, pp. 139-145, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:519112. [Accessed: 10 May 2024]

Metadata
Title (english)"Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"
AuthorGordana Zamolo
AuthorMaja Grahovac
AuthorGordana Žauhar
AuthorDamir Vučinić https://orcid.org/0000-0002-5804-0799
AuthorLeo Kovač
AuthorNika Brajenić
AuthorBlaženka Grahovac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Medical Physics and Biophysics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Background: The spread and invasion of malignant melanoma cells involve degradation and reorganization of the extracellular matrix by the activation of several matrix metalloproteinases (MMPs). This study analyzed the expression of MMP-1, MMP-2, and MMP-13 proteins in primary nodular melanoma (NM) and dysplastic nevi (DN) as a significant risk factor for melanoma development. The secondary goal was to analyze the correlation of MMPs protein expression in NM with tumor invasion, BRAF V600 mutation status, and overall survival. Methods: Immunohistochemistry for MMP-1, MMP-2, and MMP-13 was performed on nodular melanoma (n = 52) and dysplastic nevi (n = 28) on tissue microarray (TMA). BRAF V600 mutation analysis on NM samples was performed by the Sanger sequencing method. Results: A high level of MMPs expression in NM samples (>30%) compared with DN (<8%) was statistically significant (P < 0.001). BRAF V600 mutations were detected in 15 of 39 (38.5%) NM samples. This study revealed an interesting finding that MMP-1 and MMP-13 protein expression in the BRAF V600 mutated melanomas were significantly lower than in the BRAF V600 wild type (P < 0.05). Conclusion: Cox analysis revealed that Clark categories, Breslow thickness, and MMP-1 high protein expression are predictive factors for shorter overall survival (P < 0.05).
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of cutaneous pathology
Numberingvol. 47, no. 2, pp. 139-145
p-ISSN0303-6987
URN:NBNurn:nbn:hr:184:519112
Publication2020
Document URLhttp://bib.irb.hr/1050223
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-24 15:26:55