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"Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"
Journal of cutaneous pathology, 47 (2020), 2; 139-145. urn:nbn:hr:184:519112
Zamolo, Gordana; Grahovac, Maja; Žauhar, Gordana; Vučinić, Damir; Kovač, Leo; Brajenić, Nika; Grahovac, Blaženka

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Zamolo, G., Grahovac, M., Žauhar, G., Vučinić, D., Kovač, L., Brajenić, N. i Grahovac, B. (2020). "Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma". Journal of cutaneous pathology, 47. (2), 139-145. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:519112

Zamolo, Gordana, et al. ""Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"." Journal of cutaneous pathology, vol. 47, br. 2, 2020, str. 139-145. https://urn.nsk.hr/urn:nbn:hr:184:519112

Zamolo, Gordana, Maja Grahovac, Gordana Žauhar, Damir Vučinić, Leo Kovač, Nika Brajenić i Blaženka Grahovac. ""Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"." Journal of cutaneous pathology 47, br. 2 (2020): 139-145. https://urn.nsk.hr/urn:nbn:hr:184:519112

Zamolo, G., et al. (2020) '"Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"', Journal of cutaneous pathology, 47(2), str. 139-145. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:519112 (Datum pristupa: 29.12.2024.)

Zamolo G, Grahovac M, Žauhar G, Vučinić D, Kovač L, Brajenić N, i sur.. "Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma". Journal of cutaneous pathology [Internet]. 2020. [pristupljeno 29.12.2024.];47(2):139-145. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:519112

G. Zamolo, et al., ""Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"", Journal of cutaneous pathology, vol. 47, br. 2, str. 139-145, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:519112. [Citirano: 29.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:519112
Podaci o radu
Naslov (engleski)"Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma"
AutorGordana Zamolo
AutorMaja Grahovac
AutorGordana Žauhar
AutorDamir Vučinić https://orcid.org/0000-0002-5804-0799
AutorLeo Kovač
AutorNika Brajenić
AutorBlaženka Grahovac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku fiziku i biofiziku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Background: The spread and invasion of malignant melanoma cells involve degradation and reorganization of the extracellular matrix by the activation of several matrix metalloproteinases (MMPs). This study analyzed the expression of MMP-1, MMP-2, and MMP-13 proteins in primary nodular melanoma (NM) and dysplastic nevi (DN) as a significant risk factor for melanoma development. The secondary goal was to analyze the correlation of MMPs protein expression in NM with tumor invasion, BRAF V600 mutation status, and overall survival. Methods: Immunohistochemistry for MMP-1, MMP-2, and MMP-13 was performed on nodular melanoma (n = 52) and dysplastic nevi (n = 28) on tissue microarray (TMA). BRAF V600 mutation analysis on NM samples was performed by the Sanger sequencing method. Results: A high level of MMPs expression in NM samples (>30%) compared with DN (<8%) was statistically significant (P < 0.001). BRAF V600 mutations were detected in 15 of 39 (38.5%) NM samples. This study revealed an interesting finding that MMP-1 and MMP-13 protein expression in the BRAF V600 mutated melanomas were significantly lower than in the BRAF V600 wild type (P < 0.05). Conclusion: Cox analysis revealed that Clark categories, Breslow thickness, and MMP-1 high protein expression are predictive factors for shorter overall survival (P < 0.05).
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of cutaneous pathology
Brojčani podacivol. 47, br. 2, str. 139-145
p-ISSN0303-6987
URN:NBNurn:nbn:hr:184:519112
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1050223
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-24 15:26:55