prikaz prve stranice dokumenta Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up
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Scientific paper - Original scientific paper
Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864 (2018), 6; 2034-2039. https://doi.org/10.1016/j.bbadis.2018.03.018
Gudelj, Ivan; Salo, Perttu P.; Trbojević- Akmačić, Irena; Albers, Malena; Primorac, Dragan; Perola, Markus; Lauc, Gordan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Gudelj, I., Salo, P. P., Trbojević Akmačić, I., Albers, M., Primorac, D., Perola, M. & Lauc, G. (2018). Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864. (6), 2034-2039. doi: 10.1016/j.bbadis.2018.03.018

Gudelj, Ivan, et al. "Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1864, no. 6, 2018, pp. 2034-2039. https://doi.org/10.1016/j.bbadis.2018.03.018

Gudelj, Ivan, Perttu P. Salo, Irena Trbojević Akmačić, Malena Albers, Dragan Primorac, Markus Perola and Gordan Lauc. "Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864, no. 6 (2018): 2034-2039. https://doi.org/10.1016/j.bbadis.2018.03.018

Gudelj, I., et al. (2018) 'Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up', Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864(6), pp. 2034-2039. doi: 10.1016/j.bbadis.2018.03.018

Gudelj I, Salo PP, Trbojević Akmačić I, Albers M, Primorac D, Perola M, and sur.. Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease [Internet]. 2018 [cited 2024 December 21];1864(6):2034-2039. doi: 10.1016/j.bbadis.2018.03.018

I. Gudelj, et al., "Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up", Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1864, no. 6, pp. 2034-2039, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:095417. [Accessed: 21 December 2024]

Metadata
Title (english)Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up
AuthorIvan Gudelj
MBZ: 371535
AuthorPerttu P. Salo
AuthorIrena Trbojević- Akmačić
MBZ: 351184
AuthorMalena Albers
AuthorDragan Primorac
AuthorMarkus Perola
AuthorGordan Lauc
MBZ: 201852
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Antibodies are known to have an important role in the development of rheumatoid arthritis (RA), one of the most prevalent chronic inflammatory diseases which primarily involves the joints. Most RA patients develop autoantibodies against immunoglobulin G (IgG) and changes in IgG glycosylation have been associated with RA. We undertook this study to determine whether altered IgG glycosylation precedes the disease diagnosis. We studied IgG glycosylation in RA in two prospective cohorts (N = 14, 749) by measuring 28 IgG glycan traits in 179 subjects who developed RA within 10- years follow-up and 358 matched controls. Ultra-performance liquid chromatography method based on hydrophilic interactions (HILIC-UPLC) was used to analyse IgG glycans. Future RA diagnosis associated with traits related to lower galactosylation and sialylation of IgG when comparing the cases to the matched controls. In RA cases, these traits did not correlate with the time between being recruited to the study and being diagnosed with RA (median time 4.31 years). The difference in IgG glycosylation was relatively stable and present years before diagnosis. This indicates that long-acting factors affecting IgG glycome composition are among the underlying mechanisms of RA and that decreased galactosylation is a pre-existing risk factor involved in the disease development.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Numberingvol. 1864, no. 6, pp. 2034-2039
p-ISSN0925-4439
DOIhttps://doi.org/10.1016/j.bbadis.2018.03.018
URN:NBNurn:nbn:hr:184:095417
Publication2018
Document URLhttp://bib.irb.hr/1002551
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-02-25 10:02:27