prikaz prve stranice dokumenta Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up
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Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864 (2018), 6; 2034-2039. https://doi.org/10.1016/j.bbadis.2018.03.018
Gudelj, Ivan; Salo, Perttu P.; Trbojević- Akmačić, Irena; Albers, Malena; Primorac, Dragan; Perola, Markus; Lauc, Gordan

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Gudelj, I., Salo, P. P., Trbojević Akmačić, I., Albers, M., Primorac, D., Perola, M. i Lauc, G. (2018). Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864. (6), 2034-2039. doi: 10.1016/j.bbadis.2018.03.018

Gudelj, Ivan, et al. "Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1864, br. 6, 2018, str. 2034-2039. https://doi.org/10.1016/j.bbadis.2018.03.018

Gudelj, Ivan, Perttu P. Salo, Irena Trbojević Akmačić, Malena Albers, Dragan Primorac, Markus Perola i Gordan Lauc. "Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864, br. 6 (2018): 2034-2039. https://doi.org/10.1016/j.bbadis.2018.03.018

Gudelj, I., et al. (2018) 'Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up', Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864(6), str. 2034-2039. doi: 10.1016/j.bbadis.2018.03.018

Gudelj I, Salo PP, Trbojević Akmačić I, Albers M, Primorac D, Perola M, i sur.. Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease [Internet]. 2018. [pristupljeno 30.12.2024.];1864(6):2034-2039. doi: 10.1016/j.bbadis.2018.03.018

I. Gudelj, et al., "Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up", Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1864, br. 6, str. 2034-2039, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:095417. [Citirano: 30.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:095417
Podaci o radu
Naslov (engleski)Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up
AutorIvan Gudelj
MBZ: 371535
AutorPerttu P. Salo
AutorIrena Trbojević- Akmačić
MBZ: 351184
AutorMalena Albers
AutorDragan Primorac
AutorMarkus Perola
AutorGordan Lauc
MBZ: 201852
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Antibodies are known to have an important role in the development of rheumatoid arthritis (RA), one of the most prevalent chronic inflammatory diseases which primarily involves the joints. Most RA patients develop autoantibodies against immunoglobulin G (IgG) and changes in IgG glycosylation have been associated with RA. We undertook this study to determine whether altered IgG glycosylation precedes the disease diagnosis. We studied IgG glycosylation in RA in two prospective cohorts (N = 14, 749) by measuring 28 IgG glycan traits in 179 subjects who developed RA within 10- years follow-up and 358 matched controls. Ultra-performance liquid chromatography method based on hydrophilic interactions (HILIC-UPLC) was used to analyse IgG glycans. Future RA diagnosis associated with traits related to lower galactosylation and sialylation of IgG when comparing the cases to the matched controls. In RA cases, these traits did not correlate with the time between being recruited to the study and being diagnosed with RA (median time 4.31 years). The difference in IgG glycosylation was relatively stable and present years before diagnosis. This indicates that long-acting factors affecting IgG glycome composition are among the underlying mechanisms of RA and that decreased galactosylation is a pre-existing risk factor involved in the disease development.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Brojčani podacivol. 1864, br. 6, str. 2034-2039
p-ISSN0925-4439
DOIhttps://doi.org/10.1016/j.bbadis.2018.03.018
URN:NBNurn:nbn:hr:184:095417
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/1002551
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-02-25 10:02:27