prikaz prve stranice dokumenta Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma
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Scientific paper - Original scientific paper
Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma
BioMed Research International, 2016 (2016); 1-7. https://doi.org/10.1155/2016/7870590
Valković, Toni; Babarović, Emina; Lučin, Ksenija; Štifter, Sanja; Aralica, Merica; Seili-Bekafigo, Irena; Duletić-Načinović, Antica; Jonjić, Nives

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Valković, T., Babarović, E., Lučin, K., Štifter, S., Aralica, M., Seili Bekafigo, I. ... Jonjić, N. (2016). Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma. BioMed Research International, 2016., 1-7. doi: 10.1155/2016/7870590

Valković, Toni, et al. "Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma." BioMed Research International, vol. 2016, 2016, pp. 1-7. https://doi.org/10.1155/2016/7870590

Valković, Toni, Emina Babarović, Ksenija Lučin, Sanja Štifter, Merica Aralica, Irena Seili Bekafigo, Antica Duletić Načinović and Nives Jonjić. "Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma." BioMed Research International 2016 (2016): 1-7. https://doi.org/10.1155/2016/7870590

Valković, T., et al. (2016) 'Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma', BioMed Research International, 2016, pp. 1-7. doi: 10.1155/2016/7870590

Valković T, Babarović E, Lučin K, Štifter S, Aralica M, Seili Bekafigo I, and sur.. Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma. BioMed Research International [Internet]. 2016 [cited 2024 December 02];2016:1-7. doi: 10.1155/2016/7870590

T. Valković, et al., "Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma", BioMed Research International, vol. 2016, pp. 1-7, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:575434. [Accessed: 02 December 2024]

Metadata
Title (english)Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma
AuthorToni Valković
AuthorEmina Babarović
AuthorKsenija Lučin
AuthorSanja Štifter
AuthorMerica Aralica
AuthorIrena Seili-Bekafigo
AuthorAntica Duletić-Načinović
AuthorNives Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The aim of this pilot study was to determine the plasma levels of monocyte chemotactic protein-1 (MCP-1) and possible associations with angiogenesis and the main clinical features of untreated patients with multiple myeloma (MM). ELISA was used to determine plasma MCP-1 levels in 45 newly diagnosed MM patients and 24 healthy controls. The blood vessels were highlighted by immunohistochemical staining, and computer-assisted image analysis was used for more objective and accurate determination of two parameters of angiogenesis: microvessel density (MVD) and total vascular area (TVA). The plasma levels of MCP-1 were compared to these parameters and the presence of anemia, renal dysfunction, and bone lesions. A significant positive correlation was found between plasma MCP-1 concentrations and TVA ( ). The MCP-1 levels were significantly higher in MM patients with evident bone lesions ( ), renal dysfunction ( ), or anemia ( ). Therefore, our preliminary results found a positive association between plasma MCP-1 levels, angiogenesis (expressed as TVA), and clinical features in patients with MM. However, additional prospective studies with a respectable number of patients should be performed to authenticate these results and establish MCP-1 as a possible target of active treatment.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBioMed Research International
Numberingvol. 2016, pp. 1-7, 7870590
p-ISSN2314-6133
e-ISSN2314-6141
DOIhttps://doi.org/10.1155/2016/7870590
URN:NBNurn:nbn:hr:184:575434
Publication2016
ProjectNumber: 062-0620095-0079
Title (croatian): Uloga kemokina u patogenezi multiplog mijeloma
Title (english): The role of chemokines in the pathogenesis of multiple myeloma
Leader: Toni Valković
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0620095-0078
Title (croatian): Uloga osteopontina u progresiji tumora
Title (english): The role of osteopontin in tumor progression
Leader: Ksenija Lučin
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0620095-0082
Title (croatian): REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA
Title (english): REGULATORY FACTORS OF ANGIOGENESIS IN TUMORS PROGNOSIS
Leader: Nives Jonjić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-1081872-0091
Title (croatian): Angiogeneza u agresivnih ne-Hodgkinovih limfoma
Title (english): Angiogenesis in aggressive non-Hodgkins lymphoma
Leader: Antica Duletić-Načinović
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://www.hindawi.com/journals/bmri/2016/7870590/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-03-02 16:40:01