prikaz prve stranice dokumenta Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma
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Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma
BioMed Research International, 2016 (2016); 1-7. https://doi.org/10.1155/2016/7870590
Valković, Toni; Babarović, Emina; Lučin, Ksenija; Štifter, Sanja; Aralica, Merica; Seili-Bekafigo, Irena; Duletić-Načinović, Antica; Jonjić, Nives

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Valković, T., Babarović, E., Lučin, K., Štifter, S., Aralica, M., Seili Bekafigo, I. ... Jonjić, N. (2016). Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma. BioMed Research International, 2016., 1-7. doi: 10.1155/2016/7870590

Valković, Toni, et al. "Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma." BioMed Research International, vol. 2016, 2016, str. 1-7. https://doi.org/10.1155/2016/7870590

Valković, Toni, Emina Babarović, Ksenija Lučin, Sanja Štifter, Merica Aralica, Irena Seili Bekafigo, Antica Duletić Načinović i Nives Jonjić. "Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma." BioMed Research International 2016 (2016): 1-7. https://doi.org/10.1155/2016/7870590

Valković, T., et al. (2016) 'Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma', BioMed Research International, 2016, str. 1-7. doi: 10.1155/2016/7870590

Valković T, Babarović E, Lučin K, Štifter S, Aralica M, Seili Bekafigo I, i sur.. Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma. BioMed Research International [Internet]. 2016. [pristupljeno 24.12.2024.];2016:1-7. doi: 10.1155/2016/7870590

T. Valković, et al., "Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma", BioMed Research International, vol. 2016, str. 1-7, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:575434. [Citirano: 24.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:575434
Podaci o radu
Naslov (engleski)Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma
AutorToni Valković
AutorEmina Babarović
AutorKsenija Lučin
AutorSanja Štifter
AutorMerica Aralica
AutorIrena Seili-Bekafigo
AutorAntica Duletić-Načinović
AutorNives Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
The aim of this pilot study was to determine the plasma levels of monocyte chemotactic protein-1 (MCP-1) and possible associations with angiogenesis and the main clinical features of untreated patients with multiple myeloma (MM). ELISA was used to determine plasma MCP-1 levels in 45 newly diagnosed MM patients and 24 healthy controls. The blood vessels were highlighted by immunohistochemical staining, and computer-assisted image analysis was used for more objective and accurate determination of two parameters of angiogenesis: microvessel density (MVD) and total vascular area (TVA). The plasma levels of MCP-1 were compared to these parameters and the presence of anemia, renal dysfunction, and bone lesions. A significant positive correlation was found between plasma MCP-1 concentrations and TVA ( ). The MCP-1 levels were significantly higher in MM patients with evident bone lesions ( ), renal dysfunction ( ), or anemia ( ). Therefore, our preliminary results found a positive association between plasma MCP-1 levels, angiogenesis (expressed as TVA), and clinical features in patients with MM. However, additional prospective studies with a respectable number of patients should be performed to authenticate these results and establish MCP-1 as a possible target of active treatment.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBioMed Research International
Brojčani podacivol. 2016, str. 1-7, 7870590
p-ISSN2314-6133
e-ISSN2314-6141
DOIhttps://doi.org/10.1155/2016/7870590
URN:NBNurn:nbn:hr:184:575434
Datum objave publikacije2016
ProjektŠifra: 062-0620095-0079
Naziv (hrvatski): Uloga kemokina u patogenezi multiplog mijeloma
Naziv (engleski): The role of chemokines in the pathogenesis of multiple myeloma
Voditelj: Toni Valković
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0620095-0078
Naziv (hrvatski): Uloga osteopontina u progresiji tumora
Naziv (engleski): The role of osteopontin in tumor progression
Voditelj: Ksenija Lučin
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0620095-0082
Naziv (hrvatski): REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA
Naziv (engleski): REGULATORY FACTORS OF ANGIOGENESIS IN TUMORS PROGNOSIS
Voditelj: Nives Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-1081872-0091
Naziv (hrvatski): Angiogeneza u agresivnih ne-Hodgkinovih limfoma
Naziv (engleski): Angiogenesis in aggressive non-Hodgkins lymphoma
Voditelj: Antica Duletić-Načinović
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://www.hindawi.com/journals/bmri/2016/7870590/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-03-02 16:40:01