prikaz prve stranice dokumenta Subclinical Autoimmune Thyroid Dysfunction in Infertile Euthyroid Patients: The Risk of Spontaneous Abortion
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Scientific paper - Original scientific paper
Subclinical Autoimmune Thyroid Dysfunction in Infertile Euthyroid Patients: The Risk of Spontaneous Abortion
Journal of reproductive medicine, 65 (2020), 5-6; 169-174. urn:nbn:hr:184:243994
Petretić Majnarić, Silvana; Smiljan Severinski, Neda; Mrakovčić Šutić, Ines; Kustić, Domagoj; Blažević, Marina; Majnarić, Tea

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Petretić Majnarić, S., Smiljan Severinski, N., Mrakovčić Šutić, I., Kustić, D., Blažević, M. & Majnarić, T. (2020). Subclinical Autoimmune Thyroid Dysfunction in Infertile Euthyroid Patients: The Risk of Spontaneous Abortion. Journal of reproductive medicine, 65. (5-6), 169-174. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:243994

Petretić Majnarić, Silvana, et al. "Subclinical Autoimmune Thyroid Dysfunction in Infertile Euthyroid Patients: The Risk of Spontaneous Abortion." Journal of reproductive medicine, vol. 65, no. 5-6, 2020, pp. 169-174. https://urn.nsk.hr/urn:nbn:hr:184:243994

Petretić Majnarić, Silvana, Neda Smiljan Severinski, Ines Mrakovčić Šutić, Domagoj Kustić, Marina Blažević and Tea Majnarić. "Subclinical Autoimmune Thyroid Dysfunction in Infertile Euthyroid Patients: The Risk of Spontaneous Abortion." Journal of reproductive medicine 65, no. 5-6 (2020): 169-174. https://urn.nsk.hr/urn:nbn:hr:184:243994

Petretić Majnarić, S., et al. (2020) 'Subclinical Autoimmune Thyroid Dysfunction in Infertile Euthyroid Patients: The Risk of Spontaneous Abortion', Journal of reproductive medicine, 65(5-6), pp. 169-174. Available at: https://urn.nsk.hr/urn:nbn:hr:184:243994 (Accessed 07 May 2024)

Petretić Majnarić S, Smiljan Severinski N, Mrakovčić Šutić I, Kustić D, Blažević M, Majnarić T. Subclinical Autoimmune Thyroid Dysfunction in Infertile Euthyroid Patients: The Risk of Spontaneous Abortion. Journal of reproductive medicine [Internet]. 2020 [cited 2024 May 07];65(5-6):169-174. Available at: https://urn.nsk.hr/urn:nbn:hr:184:243994

S. Petretić Majnarić, N. Smiljan Severinski, I. Mrakovčić Šutić, D. Kustić, M. Blažević and T. Majnarić, "Subclinical Autoimmune Thyroid Dysfunction in Infertile Euthyroid Patients: The Risk of Spontaneous Abortion", Journal of reproductive medicine, vol. 65, no. 5-6, pp. 169-174, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:243994. [Accessed: 07 May 2024]

Metadata
Title (english)Subclinical Autoimmune Thyroid Dysfunction in Infertile Euthyroid Patients: The Risk of Spontaneous Abortion
AuthorSilvana Petretić Majnarić
AuthorNeda Smiljan Severinski
AuthorInes Mrakovčić Šutić
AuthorDomagoj Kustić
MBZ: 384580
AuthorMarina Blažević
AuthorTea Majnarić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVE: To investigate whether in vitro fertilization (IVF) procedures in patients with autoimmune thyroid disorder increase the likelihood of conception and delivery. STUDY DESIGN: The study included 125 patients (N=241 with male factor cases included) who were treated for infertility at the tertiary center between 2009 and 2015, either conservatively or by IVF. In all the participants, thyroid function was assessed by measuring serum concentrations of thyroid- stimulating hormone, free thyroxine, and free triiodothyronine, whereas thyroid autoimmunity was assessed by measuring thyroid peroxidase antibodies and thyroglobulin antibodies (TgAb) in the serum samples, and by thyroid ultrasound examinations. The reproductive outcomes were compared between the infertile patients with autoimmune thyroid disorder and patients with normal hormone levels, negative thyroid antibody tests, and normal ultrasound findings. RESULTS: In the group of patients with autoimmune thyroid disorder who were treated by IVF, significantly more women conceived. Also, significantly more women in this group had spontaneous abortions as compared to the women with euthyroid (p=0.039). The number of births per woman did not differ significantly between the groups. The percentage of births (birth per patient) was similar and without significant statistical difference. Similar results were observed in patients with autoimmune thyroid disorders and combined infertility (female- male). CONCLUSION: IVF procedures significantly increase the likelihood of conception in patients with subclinical autoimmune thyroid disorder, but not the likelihood of delivery. Despite the euthyroid status as a result of levothyroxine replacement, the risk of spontaneous abortion was increased in patients with autoimmune thyroid disorder, regardless of the type of infertility treatment (conservative or IVF).
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of reproductive medicine
Numberingvol. 65, no. 5-6, pp. 169-174
p-ISSN0024-7758
URN:NBNurn:nbn:hr:184:243994
Publication2020
Document URLhttp://bib.irb.hr/1071270
Type of resourceText
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Created on2022-03-09 15:16:09