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Scientific paper - Original scientific paper
The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma
Applied Immunohistochemistry & Molecular Morphology, 28 (2020), 5; 339-346. https://doi.org/10.1097/pai.0000000000000754
Rubeša-Mihaljević, Roberta; Babarović, Emina; Vrdoljak-Mozetič, Danijela; Štemberger- Papić, Snježana; Klarić, Marko; Krašević, Maja; Jonjić, Nives

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Rubeša Mihaljević, R., Babarović, E., Vrdoljak Mozetič, D., Štemberger Papić, S., Klarić, M., Krašević, M. & Jonjić, N. (2020). The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma. Applied Immunohistochemistry & Molecular Morphology, 28. (5), 339-346. doi: 10.1097/pai.0000000000000754

Rubeša Mihaljević, Roberta, et al. "The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma." Applied Immunohistochemistry & Molecular Morphology, vol. 28, no. 5, 2020, pp. 339-346. https://doi.org/10.1097/pai.0000000000000754

Rubeša Mihaljević, Roberta, Emina Babarović, Danijela Vrdoljak Mozetič, Snježana Štemberger Papić, Marko Klarić, Maja Krašević and Nives Jonjić. "The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma." Applied Immunohistochemistry & Molecular Morphology 28, no. 5 (2020): 339-346. https://doi.org/10.1097/pai.0000000000000754

Rubeša Mihaljević, R., et al. (2020) 'The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma', Applied Immunohistochemistry & Molecular Morphology, 28(5), pp. 339-346. doi: 10.1097/pai.0000000000000754

Rubeša Mihaljević R, Babarović E, Vrdoljak Mozetič D, Štemberger Papić S, Klarić M, Krašević M, and sur.. The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma. Applied Immunohistochemistry & Molecular Morphology [Internet]. 2020 [cited 2024 May 07];28(5):339-346. doi: 10.1097/pai.0000000000000754

R. Rubeša Mihaljević, et al., "The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma", Applied Immunohistochemistry & Molecular Morphology, vol. 28, no. 5, pp. 339-346, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:497835. [Accessed: 07 May 2024]

Metadata
Title (english)The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma
AuthorRoberta Rubeša-Mihaljević
AuthorEmina Babarović
AuthorDanijela Vrdoljak-Mozetič
AuthorSnježana Štemberger- Papić
AuthorMarko Klarić
AuthorMaja Krašević
AuthorNives Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Cytology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
The majority of endometrial carcinoma are diagnosed at an early stage and exhibit a favorable prognosis. However, 10% to 15% of ECs recur and the majority are type II tumors which are high-grade carcinomas. The epithelial-mesenchymal transition (EMT) has been considered as a fundamental step for the development of the invasive phenotype of cancer cells. During EMT, many of epithelial surface markers, primarily E-cadherin disappear, and mesenchymal markers including N-cadherin gain. This feature resides predominantly at the invasive front (IF) of the tumor. Therefore, we examined the immunohistochemical expression of E-cadherin and N-cadherin at the IF, in central areas of the tumor and lymphovascular space, in type I and type II endometrial carcinoma. The association of each protein with the clinicopathologic features was also evaluated. Our results confirmed a stronger E-cadherin immunostaining in type I tumors indicating that the loss of E-cadherin may be responsible for a more aggressive behavior of type II ECs. In both types, E-cadherin was strongly expressed in central areas and the reactivity decreased toward the IF. On contrary, N-cadherin was overexpressed at the IF confirming an inverse relationship between these markers. In addition, a decrease in E- cadherin expression was observed in cells within the lymphovascular space. Downregulation of E-cadherin was associated only with high-grade tumors while no correlations between both markers and other clinicopathologic features were found. Our results confirm that EMT occurs at the IF that represents a critical interface between the tumor and the host.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleApplied Immunohistochemistry & Molecular Morphology
Numberingvol. 28, no. 5, pp. 339-346
p-ISSN1541-2016
DOIhttps://doi.org/10.1097/pai.0000000000000754
URN:NBNurn:nbn:hr:184:497835
Publication2020
Document URLhttp://bib.irb.hr/1104989
Type of resourceText
Access conditionsClosed access
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Created on2022-03-11 08:53:30