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The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma
Applied Immunohistochemistry & Molecular Morphology, 28 (2020), 5; 339-346. https://doi.org/10.1097/pai.0000000000000754
Rubeša-Mihaljević, Roberta; Babarović, Emina; Vrdoljak-Mozetič, Danijela; Štemberger- Papić, Snježana; Klarić, Marko; Krašević, Maja; Jonjić, Nives

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Rubeša Mihaljević, R., Babarović, E., Vrdoljak Mozetič, D., Štemberger Papić, S., Klarić, M., Krašević, M. i Jonjić, N. (2020). The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma. Applied Immunohistochemistry & Molecular Morphology, 28. (5), 339-346. doi: 10.1097/pai.0000000000000754

Rubeša Mihaljević, Roberta, et al. "The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma." Applied Immunohistochemistry & Molecular Morphology, vol. 28, br. 5, 2020, str. 339-346. https://doi.org/10.1097/pai.0000000000000754

Rubeša Mihaljević, Roberta, Emina Babarović, Danijela Vrdoljak Mozetič, Snježana Štemberger Papić, Marko Klarić, Maja Krašević i Nives Jonjić. "The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma." Applied Immunohistochemistry & Molecular Morphology 28, br. 5 (2020): 339-346. https://doi.org/10.1097/pai.0000000000000754

Rubeša Mihaljević, R., et al. (2020) 'The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma', Applied Immunohistochemistry & Molecular Morphology, 28(5), str. 339-346. doi: 10.1097/pai.0000000000000754

Rubeša Mihaljević R, Babarović E, Vrdoljak Mozetič D, Štemberger Papić S, Klarić M, Krašević M, i sur.. The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma. Applied Immunohistochemistry & Molecular Morphology [Internet]. 2020. [pristupljeno 29.12.2024.];28(5):339-346. doi: 10.1097/pai.0000000000000754

R. Rubeša Mihaljević, et al., "The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma", Applied Immunohistochemistry & Molecular Morphology, vol. 28, br. 5, str. 339-346, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:497835. [Citirano: 29.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:497835
Podaci o radu
Naslov (engleski)The Immunohistochemical Pattern of Epithelial-Mesenchymal Transition Markers In Endometrial Carcinoma
AutorRoberta Rubeša-Mihaljević
AutorEmina Babarović
AutorDanijela Vrdoljak-Mozetič
AutorSnježana Štemberger- Papić
AutorMarko Klarić
AutorMaja Krašević
AutorNives Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Klinička citologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
The majority of endometrial carcinoma are diagnosed at an early stage and exhibit a favorable prognosis. However, 10% to 15% of ECs recur and the majority are type II tumors which are high-grade carcinomas. The epithelial-mesenchymal transition (EMT) has been considered as a fundamental step for the development of the invasive phenotype of cancer cells. During EMT, many of epithelial surface markers, primarily E-cadherin disappear, and mesenchymal markers including N-cadherin gain. This feature resides predominantly at the invasive front (IF) of the tumor. Therefore, we examined the immunohistochemical expression of E-cadherin and N-cadherin at the IF, in central areas of the tumor and lymphovascular space, in type I and type II endometrial carcinoma. The association of each protein with the clinicopathologic features was also evaluated. Our results confirmed a stronger E-cadherin immunostaining in type I tumors indicating that the loss of E-cadherin may be responsible for a more aggressive behavior of type II ECs. In both types, E-cadherin was strongly expressed in central areas and the reactivity decreased toward the IF. On contrary, N-cadherin was overexpressed at the IF confirming an inverse relationship between these markers. In addition, a decrease in E- cadherin expression was observed in cells within the lymphovascular space. Downregulation of E-cadherin was associated only with high-grade tumors while no correlations between both markers and other clinicopathologic features were found. Our results confirm that EMT occurs at the IF that represents a critical interface between the tumor and the host.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaApplied Immunohistochemistry & Molecular Morphology
Brojčani podacivol. 28, br. 5, str. 339-346
p-ISSN1541-2016
DOIhttps://doi.org/10.1097/pai.0000000000000754
URN:NBNurn:nbn:hr:184:497835
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1104989
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-11 08:53:30