prikaz prve stranice dokumenta The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis
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Scientific paper - Review paper
The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis
Acta Dermatovenerologica Croatica, 27 (2019), 3; 159-162. urn:nbn:hr:184:787665
Volarić, Iva; Vičić, Marijana; Prpić-Massari, Larisa

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Volarić, I., Vičić, M. & Prpić Massari, L. (2019). The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis. Acta Dermatovenerologica Croatica, 27. (3), 159-162. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:787665

Volarić, Iva, et al. "The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis." Acta Dermatovenerologica Croatica, vol. 27, no. 3, 2019, pp. 159-162. https://urn.nsk.hr/urn:nbn:hr:184:787665

Volarić, Iva, Marijana Vičić and Larisa Prpić Massari. "The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis." Acta Dermatovenerologica Croatica 27, no. 3 (2019): 159-162. https://urn.nsk.hr/urn:nbn:hr:184:787665

Volarić, I., Vičić, M. and Prpić Massari, L. (2019) 'The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis', Acta Dermatovenerologica Croatica, 27(3), pp. 159-162. Available at: https://urn.nsk.hr/urn:nbn:hr:184:787665 (Accessed 25 April 2024)

Volarić I, Vičić M, Prpić Massari L. The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis. Acta Dermatovenerologica Croatica [Internet]. 2019 [cited 2024 April 25];27(3):159-162. Available at: https://urn.nsk.hr/urn:nbn:hr:184:787665

I. Volarić, M. Vičić and L. Prpić Massari, "The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis", Acta Dermatovenerologica Croatica, vol. 27, no. 3, pp. 159-162, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:787665. [Accessed: 25 April 2024]

Metadata
Title (english)The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis
AuthorIva Volarić
AuthorMarijana Vičić
AuthorLarisa Prpić-Massari
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
The important role of CD8(+) T-cells in the pathogenesis of psoriasis is well-determined. However, besides type 1 cytokines that were formerly known, it was recently found that these cells secrete type 17 and type 22 cytokines. The majority of IL-17A(+)CD8(+) T- cells in the blood belong to a subset of innate T-cells named mucosa-associated invariant T- cells (MAIT). However, the majority of IL- 17A(+)CD8(+) T-cells in psoriatic epidermis are conventional T-cells and are up-regulated in psoriasis. In contrast to Th17 cells that secrete only IL-17, Tc17 cells secrete IFN- gamma, TNF-alpha, CCL20, IL-22, and granzyme B as well. The key cytokine is IL-17A, which promotes keratinocyte hyperproliferation and stimulates them to produce other proinflammatory cytokines. These activities initiate and propagate the inflammation and architectural changes in the skin that clinically manifest as psoriatic lesions. However, a relatively novel cell subtype named Tc22 has been discovered in psoriasis that could secrete IL-22 in the absence of IL-17 and IFN-gamma. IL-22 stimulates proliferation and de-differentiation of keratinocytes, subsequently leading to epidermal acanthosis. As the understanding of the pathogenesis of psoriasis increases, the new selective therapies may offer an optimal balance between increased clinical benefit and reduced risk of side-effects.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa Dermatovenerologica Croatica
Numberingvol. 27, no. 3, pp. 159-162
p-ISSN1330-027X
e-ISSN1847-6538
URN:NBNurn:nbn:hr:184:787665
Publication2019
Document URLhttp://bib.irb.hr/1050179
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-03-11 14:06:22