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The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis
Acta Dermatovenerologica Croatica, 27 (2019), 3; 159-162. urn:nbn:hr:184:787665
Volarić, Iva; Vičić, Marijana; Prpić-Massari, Larisa

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Volarić, I., Vičić, M. i Prpić Massari, L. (2019). The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis. Acta Dermatovenerologica Croatica, 27. (3), 159-162. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:787665

Volarić, Iva, et al. "The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis." Acta Dermatovenerologica Croatica, vol. 27, br. 3, 2019, str. 159-162. https://urn.nsk.hr/urn:nbn:hr:184:787665

Volarić, Iva, Marijana Vičić i Larisa Prpić Massari. "The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis." Acta Dermatovenerologica Croatica 27, br. 3 (2019): 159-162. https://urn.nsk.hr/urn:nbn:hr:184:787665

Volarić, I., Vičić, M. i Prpić Massari, L. (2019) 'The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis', Acta Dermatovenerologica Croatica, 27(3), str. 159-162. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:787665 (Datum pristupa: 08.11.2024.)

Volarić I, Vičić M, Prpić Massari L. The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis. Acta Dermatovenerologica Croatica [Internet]. 2019. [pristupljeno 08.11.2024.];27(3):159-162. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:787665

I. Volarić, M. Vičić i L. Prpić Massari, "The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis", Acta Dermatovenerologica Croatica, vol. 27, br. 3, str. 159-162, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:787665. [Citirano: 08.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:787665
Podaci o radu
Naslov (engleski)The Role of Cd8(+) T-Cells and their Cytokines in the Pathogenesis of Psoriasis
AutorIva Volarić
AutorMarijana Vičić
AutorLarisa Prpić-Massari
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za dermatovenerologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
The important role of CD8(+) T-cells in the pathogenesis of psoriasis is well-determined. However, besides type 1 cytokines that were formerly known, it was recently found that these cells secrete type 17 and type 22 cytokines. The majority of IL-17A(+)CD8(+) T- cells in the blood belong to a subset of innate T-cells named mucosa-associated invariant T- cells (MAIT). However, the majority of IL- 17A(+)CD8(+) T-cells in psoriatic epidermis are conventional T-cells and are up-regulated in psoriasis. In contrast to Th17 cells that secrete only IL-17, Tc17 cells secrete IFN- gamma, TNF-alpha, CCL20, IL-22, and granzyme B as well. The key cytokine is IL-17A, which promotes keratinocyte hyperproliferation and stimulates them to produce other proinflammatory cytokines. These activities initiate and propagate the inflammation and architectural changes in the skin that clinically manifest as psoriatic lesions. However, a relatively novel cell subtype named Tc22 has been discovered in psoriasis that could secrete IL-22 in the absence of IL-17 and IFN-gamma. IL-22 stimulates proliferation and de-differentiation of keratinocytes, subsequently leading to epidermal acanthosis. As the understanding of the pathogenesis of psoriasis increases, the new selective therapies may offer an optimal balance between increased clinical benefit and reduced risk of side-effects.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Dermatovenerologica Croatica
Brojčani podacivol. 27, br. 3, str. 159-162
p-ISSN1330-027X
e-ISSN1847-6538
URN:NBNurn:nbn:hr:184:787665
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1050179
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-03-11 14:06:22