prikaz prve stranice dokumenta CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals
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Scientific paper - Original scientific paper
CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals
Journal of immunology, 181 (2008), 3; 2111-2123. urn:nbn:hr:184:775455
Bantug, Glenn Robert; Cekinović, Đurđica; Bradford, Russell; Koontz, T.; Jonjić, Stipan; Britt, W.

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Bantug, G. R., Cekinović, Đ., Bradford, R., Koontz, T., Jonjić, S. & Britt, W. (2008). CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals. Journal of immunology, 181. (3), 2111-2123. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:775455

Bantug, Glenn Robert, et al. "CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals." Journal of immunology, vol. 181, no. 3, 2008, pp. 2111-2123. https://urn.nsk.hr/urn:nbn:hr:184:775455

Bantug, Glenn Robert, Đurđica Cekinović, Russell Bradford, T. Koontz, Stipan Jonjić and W. Britt. "CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals." Journal of immunology 181, no. 3 (2008): 2111-2123. https://urn.nsk.hr/urn:nbn:hr:184:775455

Bantug, G. R., et al. (2008) 'CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals', Journal of immunology, 181(3), pp. 2111-2123. Available at: https://urn.nsk.hr/urn:nbn:hr:184:775455 (Accessed 14 May 2024)

Bantug GR, Cekinović Đ, Bradford R, Koontz T, Jonjić S, Britt W. CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals. Journal of immunology [Internet]. 2008 [cited 2024 May 14];181(3):2111-2123. Available at: https://urn.nsk.hr/urn:nbn:hr:184:775455

G. R. Bantug, Đ. Cekinović, R. Bradford, T. Koontz, S. Jonjić and W. Britt, "CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals", Journal of immunology, vol. 181, no. 3, pp. 2111-2123, 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:775455. [Accessed: 14 May 2024]

Metadata
Title (english)CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals
Title (english)CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals1
AuthorGlenn Robert Bantug
AuthorĐurđica Cekinović
AuthorRussell Bradford
AuthorT. Koontz
AuthorStipan Jonjić
AuthorW. Britt
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Human CMV infection of the neonatal CNS results in long-term neurologic sequelae. To define the pathogenesis of fetal human CMV CNS infections, we investigated mechanisms of virus clearance from the CNS of neonatal BALB/c mice infected with murine CMV (MCMV). Virus titers peaked in the CNS between postnatal days 10–14 and infectious virus was undetectable by postnatal day 21. Congruent with virus clearance was the recruitment of CD8+ T cells into the CNS. Depletion of CD8+ T cells resulted in death by postnatal day 15 in MCMV-infected animals and increased viral loads in the liver, spleen, and the CNS, suggesting an important role for these cells in the control of MCMV replication in the newborn brain. Examination of brain mononuclear cells revealed that CD8+ T cell infiltrates expressed high levels of CD69, CD44, and CD49d. IE1168-specific CD8+ T cells accumulated in the CNS and produced IFN-γ and TNF-α but not IL-2 following peptide stimulation. Moreover, adoptive transfer of brain mononuclear cells resulted in decreased virus burden in immunodepleted MCMV-infected syngeneic mice. Depletion of the CD8+ cell population following transfer eliminated control of virus replication. In summary, these results show that functionally mature virus-specific CD8+ T cells are recruited to the CNS in mice infected with MCMV as neonates.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of immunology
Numberingvol. 181, no. 3, pp. 2111-2123
p-ISSN0022-1767
URN:NBNurn:nbn:hr:184:775455
Publication2008
Document URLhttp://bib.irb.hr/556947
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-03-24 14:41:26