prikaz prve stranice dokumenta CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals
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CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals
Journal of immunology, 181 (2008), 3; 2111-2123. urn:nbn:hr:184:775455
Bantug, Glenn Robert; Cekinović, Đurđica; Bradford, Russell; Koontz, T.; Jonjić, Stipan; Britt, W.

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Bantug, G. R., Cekinović, Đ., Bradford, R., Koontz, T., Jonjić, S. i Britt, W. (2008). CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals. Journal of immunology, 181. (3), 2111-2123. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:775455

Bantug, Glenn Robert, et al. "CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals." Journal of immunology, vol. 181, br. 3, 2008, str. 2111-2123. https://urn.nsk.hr/urn:nbn:hr:184:775455

Bantug, Glenn Robert, Đurđica Cekinović, Russell Bradford, T. Koontz, Stipan Jonjić i W. Britt. "CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals." Journal of immunology 181, br. 3 (2008): 2111-2123. https://urn.nsk.hr/urn:nbn:hr:184:775455

Bantug, G. R., et al. (2008) 'CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals', Journal of immunology, 181(3), str. 2111-2123. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:775455 (Datum pristupa: 15.05.2024.)

Bantug GR, Cekinović Đ, Bradford R, Koontz T, Jonjić S, Britt W. CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals. Journal of immunology [Internet]. 2008. [pristupljeno 15.05.2024.];181(3):2111-2123. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:775455

G. R. Bantug, Đ. Cekinović, R. Bradford, T. Koontz, S. Jonjić i W. Britt, "CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals", Journal of immunology, vol. 181, br. 3, str. 2111-2123, 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:775455. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:775455
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Naslov (engleski)CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals
Naslov (engleski)CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals1
AutorGlenn Robert Bantug
AutorĐurđica Cekinović
AutorRussell Bradford
AutorT. Koontz
AutorStipan Jonjić
AutorW. Britt
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Human CMV infection of the neonatal CNS results in long-term neurologic sequelae. To define the pathogenesis of fetal human CMV CNS infections, we investigated mechanisms of virus clearance from the CNS of neonatal BALB/c mice infected with murine CMV (MCMV). Virus titers peaked in the CNS between postnatal days 10–14 and infectious virus was undetectable by postnatal day 21. Congruent with virus clearance was the recruitment of CD8+ T cells into the CNS. Depletion of CD8+ T cells resulted in death by postnatal day 15 in MCMV-infected animals and increased viral loads in the liver, spleen, and the CNS, suggesting an important role for these cells in the control of MCMV replication in the newborn brain. Examination of brain mononuclear cells revealed that CD8+ T cell infiltrates expressed high levels of CD69, CD44, and CD49d. IE1168-specific CD8+ T cells accumulated in the CNS and produced IFN-γ and TNF-α but not IL-2 following peptide stimulation. Moreover, adoptive transfer of brain mononuclear cells resulted in decreased virus burden in immunodepleted MCMV-infected syngeneic mice. Depletion of the CD8+ cell population following transfer eliminated control of virus replication. In summary, these results show that functionally mature virus-specific CD8+ T cells are recruited to the CNS in mice infected with MCMV as neonates.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of immunology
Brojčani podacivol. 181, br. 3, str. 2111-2123
p-ISSN0022-1767
URN:NBNurn:nbn:hr:184:775455
Datum objave publikacije2008
URL dokumentahttp://bib.irb.hr/556947
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-24 14:41:26