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Scientific paper - Original scientific paper
Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis
Collegium antropologicum, 34 supplement 2 (2010), 2; 61-64. urn:nbn:hr:184:464934
Španjol, Josip; Đorđevic, Gordana; Markić, Dean; Fučkar, Dora; Krpina, Kristian; Bobinac, Dragica

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Španjol, J., Đorđevic, G., Markić, D., Fučkar, D., Krpina, K. & Bobinac, D. (2010). Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis. Collegium antropologicum, 34 supplement 2. (2), 61-64. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:464934

Španjol, Josip, et al. "Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis." Collegium antropologicum, vol. 34 supplement 2, no. 2, 2010, pp. 61-64. https://urn.nsk.hr/urn:nbn:hr:184:464934

Španjol, Josip, Gordana Đorđevic, Dean Markić, Dora Fučkar, Kristian Krpina and Dragica Bobinac. "Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis." Collegium antropologicum 34 supplement 2, no. 2 (2010): 61-64. https://urn.nsk.hr/urn:nbn:hr:184:464934

Španjol, J., et al. (2010) 'Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis', Collegium antropologicum, 34 supplement 2(2), pp. 61-64. Available at: https://urn.nsk.hr/urn:nbn:hr:184:464934 (Accessed 30 April 2024)

Španjol J, Đorđevic G, Markić D, Fučkar D, Krpina K, Bobinac D. Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis. Collegium antropologicum [Internet]. 2010 [cited 2024 April 30];34 supplement 2(2):61-64. Available at: https://urn.nsk.hr/urn:nbn:hr:184:464934

J. Španjol, G. Đorđevic, D. Markić, D. Fučkar, K. Krpina and D. Bobinac, "Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis", Collegium antropologicum, vol. 34 supplement 2, no. 2, pp. 61-64, 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:464934. [Accessed: 30 April 2024]

Metadata
Title (english)Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis
AuthorJosip Španjol
AuthorGordana Đorđevic
AuthorDean Markić
AuthorDora Fučkar
AuthorKristian Krpina
AuthorDragica Bobinac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
Bone morphogenetic protein 7 (BMP-7) is a member of the transforming growth factor (TGF) beta superfamily and is involved in regeneration, repair, and development of specific tissues, for example kidney and skeleton1–5. The experimental studies have shown its protective role against fibrotic processes. Tubulointerstitial changes are present in the pyelonephritic kidney which progresses to fibrosis4–6. Renal fibrosis may lead to the loss of renal function. The aim of this study was to investigate BMP-7 expression in acute and chronic pyelonephritis in humans. Seven patients with acute pyelonephritis and 7 with chronic pyelonephritis were treated in Department of Nephrology Clinical Hospital, Rijeka. Tissue biopsy was taken and renal tissue was studied histopathologically by use of hematoxylin and eosin and scored for diagnosis of pyelonephritis. BMP-7 expression was studied by imunohistochemical staining. BMP-7 expression was observed in the tubular area of the pyelonephritic kidneys. The expression of BMP-7 was stronger in the acute pyelonephritic group and less in the chronic pyelonephritic group of patients. The results imply that BMP-7 has a role in chronic pyelonephritis. Tubular BMP-7 expression had a negative correlation with fibrosis and tubular, atrophy. Our results are suggesting that BMP-7 plays an important protective role in renal inflammatory diseases preventing greater damage and fibrosis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 34 supplement 2, no. 2, pp. 61-64
p-ISSN0350-6134
e-ISSN1848-9486
URN:NBNurn:nbn:hr:184:464934
Publication2010
Document URLhttps://hrcak.srce.hr/51630
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-04-01 15:21:24