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Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis
Collegium antropologicum, 34 supplement 2 (2010), 2; 61-64. urn:nbn:hr:184:464934
Španjol, Josip; Đorđevic, Gordana; Markić, Dean; Fučkar, Dora; Krpina, Kristian; Bobinac, Dragica

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Španjol, J., Đorđevic, G., Markić, D., Fučkar, D., Krpina, K. i Bobinac, D. (2010). Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis. Collegium antropologicum, 34 supplement 2. (2), 61-64. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:464934

Španjol, Josip, et al. "Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis." Collegium antropologicum, vol. 34 supplement 2, br. 2, 2010, str. 61-64. https://urn.nsk.hr/urn:nbn:hr:184:464934

Španjol, Josip, Gordana Đorđevic, Dean Markić, Dora Fučkar, Kristian Krpina i Dragica Bobinac. "Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis." Collegium antropologicum 34 supplement 2, br. 2 (2010): 61-64. https://urn.nsk.hr/urn:nbn:hr:184:464934

Španjol, J., et al. (2010) 'Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis', Collegium antropologicum, 34 supplement 2(2), str. 61-64. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:464934 (Datum pristupa: 09.05.2024.)

Španjol J, Đorđevic G, Markić D, Fučkar D, Krpina K, Bobinac D. Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis. Collegium antropologicum [Internet]. 2010. [pristupljeno 09.05.2024.];34 supplement 2(2):61-64. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:464934

J. Španjol, G. Đorđevic, D. Markić, D. Fučkar, K. Krpina i D. Bobinac, "Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis", Collegium antropologicum, vol. 34 supplement 2, br. 2, str. 61-64, 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:464934. [Citirano: 09.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:464934
Podaci o radu
Naslov (engleski)Bone Morphogenetic Protein-7 Expression in Human Pyelonephritis
AutorJosip Španjol
AutorGordana Đorđevic
AutorDean Markić
AutorDora Fučkar
AutorKristian Krpina
AutorDragica Bobinac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za urologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Urologija
Sažetak (engleski)
Bone morphogenetic protein 7 (BMP-7) is a member of the transforming growth factor (TGF) beta superfamily and is involved in regeneration, repair, and development of specific tissues, for example kidney and skeleton1–5. The experimental studies have shown its protective role against fibrotic processes. Tubulointerstitial changes are present in the pyelonephritic kidney which progresses to fibrosis4–6. Renal fibrosis may lead to the loss of renal function. The aim of this study was to investigate BMP-7 expression in acute and chronic pyelonephritis in humans. Seven patients with acute pyelonephritis and 7 with chronic pyelonephritis were treated in Department of Nephrology Clinical Hospital, Rijeka. Tissue biopsy was taken and renal tissue was studied histopathologically by use of hematoxylin and eosin and scored for diagnosis of pyelonephritis. BMP-7 expression was studied by imunohistochemical staining. BMP-7 expression was observed in the tubular area of the pyelonephritic kidneys. The expression of BMP-7 was stronger in the acute pyelonephritic group and less in the chronic pyelonephritic group of patients. The results imply that BMP-7 has a role in chronic pyelonephritis. Tubular BMP-7 expression had a negative correlation with fibrosis and tubular, atrophy. Our results are suggesting that BMP-7 plays an important protective role in renal inflammatory diseases preventing greater damage and fibrosis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium antropologicum
Brojčani podacivol. 34 supplement 2, br. 2, str. 61-64
p-ISSN0350-6134
e-ISSN1848-9486
URN:NBNurn:nbn:hr:184:464934
Datum objave publikacije2010
URL dokumentahttps://hrcak.srce.hr/51630
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-04-01 15:21:24