prikaz prve stranice dokumenta Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus
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Scientific paper - Preliminary note / Short communication
Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus
Acta Dermato-Venereologica, 101 (2021), 7; Adv00499. https://doi.org/10.2340/00015555-3863
Vičić, Marijana; Brajac, Ines; Kaštelan, Marija; Sotošek, Vlatka; Prpić Massari, Larisa

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Vičić, M., Brajac, I., Kaštelan, M., Sotošek, V. & Prpić Massari, L. (2021). Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus. Acta Dermato-Venereologica, 101. (7). doi: 10.2340/00015555-3863

Vičić, Marijana, et al. "Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus." Acta Dermato-Venereologica, vol. 101, no. 7, 2021. https://doi.org/10.2340/00015555-3863

Vičić, Marijana, Ines Brajac, Marija Kaštelan, Vlatka Sotošek and Larisa Prpić Massari. "Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus." Acta Dermato-Venereologica 101, no. 7 (2021). https://doi.org/10.2340/00015555-3863

Vičić, M., et al. (2021) 'Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus', Acta Dermato-Venereologica, 101(7). doi: 10.2340/00015555-3863

Vičić M, Brajac I, Kaštelan M, Sotošek V, Prpić Massari L. Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus. Acta Dermato-Venereologica [Internet]. 2021 [cited 2024 December 28];101(7). doi: 10.2340/00015555-3863

M. Vičić, I. Brajac, M. Kaštelan, V. Sotošek and L. Prpić Massari, "Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus", Acta Dermato-Venereologica, vol. 101, no. 7, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:167685. [Accessed: 28 December 2024]

Metadata
Title (english)Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus
AuthorMarijana Vičić
AuthorInes Brajac
AuthorMarija Kaštelan
AuthorVlatka Sotošek
AuthorLarisa Prpić Massari
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Lichen planus is a chronic inflammatory mucocutaneous disorder commonly affecting the skin, nails, hair, and mucous membranes (1). Although its main cause is still unclear, lichen planus is defined as a T cell- mediated inflammatory disease (2). CD8+ T lymphocytes activate their cytotoxic armamentarium and induce basal keratinocyte apoptosis (2). The susceptibility of basal keratinocytes to CD8+ T lymphocytes is enhanced through MHC class I expression on keratinocytes triggered by interferon (IFN)- gamma (3). The cytotoxic process is mainly mediated by the release of lytic molecules, such as perforin, granzyme B, and granulysin (GNLY) (4–8). The upregulation of perforin and granzyme B has been previously demonstrated in the peripheral blood and lesional skin of patients with lichen planus (4–8). GNLY is a member of the saposin-like lipid-binding protein (SAPLIP) family and has a cytotoxic effect on tumour cells and a variety of microorganisms (9, 10). It is located in the cytotoxic granules of T cells, which are released upon antigen stimulation, and in the cytotoxic granules of natural killer (NK) cells. GNLY presence has only recently been observed in lichen planus lesions, but the expression level of this molecule in peripheral blood and subsequent determination of cells that express this molecule in blood and lesions remains unknown (8). In this study we examined the dynamics of GNLY expression in different cytotoxic subtypes of peripheral blood lymphocytes and in the skin lesions of patients with lichen planus.
Keywords (english)
Languageenglish
Publication typeScientific paper - Preliminary note / Short communication
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Dermato-Venereologica
Numberingvol. 101, no. 7, Adv00499
p-ISSN0001-5555
e-ISSN1651-2057
DOIhttps://doi.org/10.2340/00015555-3863
URN:NBNurn:nbn:hr:184:167685
Publication2021
ProjectNumber: uniri-biomed-18-83
Title (croatian): Uloga citotoksičnosti posredovane granulizinom i perforinom 2 u nastanku psorijaze i lihen planusa
Title (english): The role of cytotoxicity mediated by granulysin and perforin-2 in the development of psoriasis and lichen planus
Leader: Larisa Prpić Massari
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttp://bib.irb.hr/1183588
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) icon
Created on2022-04-12 07:22:04