prikaz prve stranice dokumenta Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus
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Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus
Acta Dermato-Venereologica, 101 (2021), 7; Adv00499. https://doi.org/10.2340/00015555-3863
Vičić, Marijana; Brajac, Ines; Kaštelan, Marija; Sotošek, Vlatka; Prpić Massari, Larisa

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Vičić, M., Brajac, I., Kaštelan, M., Sotošek, V. i Prpić Massari, L. (2021). Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus. Acta Dermato-Venereologica, 101. (7). doi: 10.2340/00015555-3863

Vičić, Marijana, et al. "Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus." Acta Dermato-Venereologica, vol. 101, br. 7, 2021. https://doi.org/10.2340/00015555-3863

Vičić, Marijana, Ines Brajac, Marija Kaštelan, Vlatka Sotošek i Larisa Prpić Massari. "Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus." Acta Dermato-Venereologica 101, br. 7 (2021). https://doi.org/10.2340/00015555-3863

Vičić, M., et al. (2021) 'Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus', Acta Dermato-Venereologica, 101(7). doi: 10.2340/00015555-3863

Vičić M, Brajac I, Kaštelan M, Sotošek V, Prpić Massari L. Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus. Acta Dermato-Venereologica [Internet]. 2021. [pristupljeno 01.05.2024.];101(7). doi: 10.2340/00015555-3863

M. Vičić, I. Brajac, M. Kaštelan, V. Sotošek i L. Prpić Massari, "Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus", Acta Dermato-Venereologica, vol. 101, br. 7, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:167685. [Citirano: 01.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:167685
Podaci o radu
Naslov (engleski)Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus
AutorMarijana Vičić
AutorInes Brajac
AutorMarija Kaštelan
AutorVlatka Sotošek
AutorLarisa Prpić Massari
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za dermatovenerologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
Lichen planus is a chronic inflammatory mucocutaneous disorder commonly affecting the skin, nails, hair, and mucous membranes (1). Although its main cause is still unclear, lichen planus is defined as a T cell- mediated inflammatory disease (2). CD8+ T lymphocytes activate their cytotoxic armamentarium and induce basal keratinocyte apoptosis (2). The susceptibility of basal keratinocytes to CD8+ T lymphocytes is enhanced through MHC class I expression on keratinocytes triggered by interferon (IFN)- gamma (3). The cytotoxic process is mainly mediated by the release of lytic molecules, such as perforin, granzyme B, and granulysin (GNLY) (4–8). The upregulation of perforin and granzyme B has been previously demonstrated in the peripheral blood and lesional skin of patients with lichen planus (4–8). GNLY is a member of the saposin-like lipid-binding protein (SAPLIP) family and has a cytotoxic effect on tumour cells and a variety of microorganisms (9, 10). It is located in the cytotoxic granules of T cells, which are released upon antigen stimulation, and in the cytotoxic granules of natural killer (NK) cells. GNLY presence has only recently been observed in lichen planus lesions, but the expression level of this molecule in peripheral blood and subsequent determination of cells that express this molecule in blood and lesions remains unknown (8). In this study we examined the dynamics of GNLY expression in different cytotoxic subtypes of peripheral blood lymphocytes and in the skin lesions of patients with lichen planus.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prethodno/kratko priopćenje
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Dermato-Venereologica
Brojčani podacivol. 101, br. 7, Adv00499
p-ISSN0001-5555
e-ISSN1651-2057
DOIhttps://doi.org/10.2340/00015555-3863
URN:NBNurn:nbn:hr:184:167685
Datum objave publikacije2021
ProjektŠifra: uniri-biomed-18-83
Naziv (hrvatski): Uloga citotoksičnosti posredovane granulizinom i perforinom 2 u nastanku psorijaze i lihen planusa
Naziv (engleski): The role of cytotoxicity mediated by granulysin and perforin-2 in the development of psoriasis and lichen planus
Voditelj: Larisa Prpić Massari
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttp://bib.irb.hr/1183588
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-NC-SA 4.0)
Datum i vrijeme pohrane2022-04-12 07:22:04