prikaz prve stranice dokumenta Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus
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Scientific paper - Original scientific paper
Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus
Journal of Diabetes and its Complications, 36 (2022), 8; 108226. https://doi.org/10.1016/j.jdiacomp.2022.108226
Mikolašević, Ivana; Domislovic, V.; Ružić, Alen; Hauser, Goran; Rahelic, Dario; Klobučar-Majanović, Sanja; Krznarić, Ž.; Dobrila-Dintinjana, Renata; Grgurevic, I.; Skenderević, N.; Lukić, A.; Targher, G.

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Cite this document

Mikolašević, I., Domislovic, V., Ružić, A., Hauser, G., Rahelic, D., Klobučar Majanović, S. ... Targher, G. (2022). Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus. Journal of Diabetes and its Complications, 36. (8). doi: 10.1016/j.jdiacomp.2022.108226

Mikolašević, Ivana, et al. "Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus." Journal of Diabetes and its Complications, vol. 36, no. 8, 2022. https://doi.org/10.1016/j.jdiacomp.2022.108226

Mikolašević, Ivana, V. Domislovic, Alen Ružić, Goran Hauser, Dario Rahelic, Sanja Klobučar Majanović, Ž. Krznarić, et al. "Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus." Journal of Diabetes and its Complications 36, no. 8 (2022). https://doi.org/10.1016/j.jdiacomp.2022.108226

Mikolašević, I., et al. (2022) 'Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus', Journal of Diabetes and its Complications, 36(8). doi: 10.1016/j.jdiacomp.2022.108226

Mikolašević I, Domislovic V, Ružić A, Hauser G, Rahelic D, Klobučar Majanović S, and sur.. Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus. Journal of Diabetes and its Complications [Internet]. 2022 August [cited 2024 December 26];36(8). doi: 10.1016/j.jdiacomp.2022.108226

I. Mikolašević, et al., "Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus", Journal of Diabetes and its Complications, vol. 36, no. 8, August 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:544419. [Accessed: 26 December 2024]

Metadata
Title (english)Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus
AuthorIvana Mikolašević
AuthorV. Domislovic
AuthorAlen Ružić
AuthorGoran Hauser
AuthorDario Rahelic
AuthorSanja Klobučar-Majanović
AuthorŽ. Krznarić
AuthorRenata Dobrila-Dintinjana
AuthorI. Grgurevic
AuthorN. Skenderević
AuthorA. Lukić
AuthorG. Targher
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aims: The aim of this prospective study was to examine the relationship between controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) with the risk of developing a composite endpoint inclusive of incident acute myocardial infarction (AMI), cerebrovascular insult (CVI) or chronic kidney disease (CKD) in people with type 2 diabetes mellitus (T2DM). Methods: This study included 238 T2DM outpatients without chronic liver diseases. Results: The patient population was followed for a median period of 7.6 years. Kaplan-Meier survival analyses showed that there was a higher proportion of patients who developed the aforementioned composite outcome (P < 0.001 by the log-rank test), as well as CKD (P < 0.001) or AMI alone (P = 0.014) among those with elevated CAP values (≥238 dB/m) at baseline. Similarly, Kaplan-Meier survival analyses showed that there was a higher proportion of patients who developed the composite outcome (P < 0.001), as well as CKD (P < 0.001), or AMI alone (P < 0.001) among those with elevated LSM values (≥7.0/6.2 kPa). In multivariable regression analyses, the presence of elevated CAP (adjusted-hazard ratio 2.34, 95% CI 1.32–4.15) and elevated LSM (adjusted-hazard ratio 2.84, 95% CI 1.92–4.21), independently of each other, were associated with a higher risk of developing the composite outcome, as well as incident AMI or CKD alone after adjusting for traditional cardiovascular risk factors and diabetes-related variables. Conclusions: Our study shows that the elastographic parameters of liver steatosis and fibrosis independently predict the long-term risk of developing chronic vascular complications in T2DM patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Diabetes and its Complications
Numberingvol. 36, no. 8, 108226
p-ISSN1056-8727
DOIhttps://doi.org/10.1016/j.jdiacomp.2022.108226
URN:NBNurn:nbn:hr:184:544419
Publication2022-08
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1056872722001325
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-09-20 13:18:11