prikaz prve stranice dokumenta Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus
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Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus
Journal of Diabetes and its Complications, 36 (2022), 8; 108226. https://doi.org/10.1016/j.jdiacomp.2022.108226
Mikolašević, Ivana; Domislovic, V.; Ružić, Alen; Hauser, Goran; Rahelic, Dario; Klobučar-Majanović, Sanja; Krznarić, Ž.; Dobrila-Dintinjana, Renata; Grgurevic, I.; Skenderević, N.; Lukić, A.; Targher, G.

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Mikolašević, I., Domislovic, V., Ružić, A., Hauser, G., Rahelic, D., Klobučar Majanović, S. ... Targher, G. (2022). Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus. Journal of Diabetes and its Complications, 36. (8). doi: 10.1016/j.jdiacomp.2022.108226

Mikolašević, Ivana, et al. "Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus." Journal of Diabetes and its Complications, vol. 36, br. 8, 2022. https://doi.org/10.1016/j.jdiacomp.2022.108226

Mikolašević, Ivana, V. Domislovic, Alen Ružić, Goran Hauser, Dario Rahelic, Sanja Klobučar Majanović, Ž. Krznarić, et al. "Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus." Journal of Diabetes and its Complications 36, br. 8 (2022). https://doi.org/10.1016/j.jdiacomp.2022.108226

Mikolašević, I., et al. (2022) 'Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus', Journal of Diabetes and its Complications, 36(8). doi: 10.1016/j.jdiacomp.2022.108226

Mikolašević I, Domislovic V, Ružić A, Hauser G, Rahelic D, Klobučar Majanović S, i sur.. Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus. Journal of Diabetes and its Complications [Internet]. 08.2022. [pristupljeno 30.04.2024.];36(8). doi: 10.1016/j.jdiacomp.2022.108226

I. Mikolašević, et al., "Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus", Journal of Diabetes and its Complications, vol. 36, br. 8, Kolovoz 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:544419. [Citirano: 30.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:544419
Podaci o radu
Naslov (engleski)Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus
AutorIvana Mikolašević
AutorV. Domislovic
AutorAlen Ružić
AutorGoran Hauser
AutorDario Rahelic
AutorSanja Klobučar-Majanović
AutorŽ. Krznarić
AutorRenata Dobrila-Dintinjana
AutorI. Grgurevic
AutorN. Skenderević
AutorA. Lukić
AutorG. Targher
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Aims: The aim of this prospective study was to examine the relationship between controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) with the risk of developing a composite endpoint inclusive of incident acute myocardial infarction (AMI), cerebrovascular insult (CVI) or chronic kidney disease (CKD) in people with type 2 diabetes mellitus (T2DM). Methods: This study included 238 T2DM outpatients without chronic liver diseases. Results: The patient population was followed for a median period of 7.6 years. Kaplan-Meier survival analyses showed that there was a higher proportion of patients who developed the aforementioned composite outcome (P < 0.001 by the log-rank test), as well as CKD (P < 0.001) or AMI alone (P = 0.014) among those with elevated CAP values (≥238 dB/m) at baseline. Similarly, Kaplan-Meier survival analyses showed that there was a higher proportion of patients who developed the composite outcome (P < 0.001), as well as CKD (P < 0.001), or AMI alone (P < 0.001) among those with elevated LSM values (≥7.0/6.2 kPa). In multivariable regression analyses, the presence of elevated CAP (adjusted-hazard ratio 2.34, 95% CI 1.32–4.15) and elevated LSM (adjusted-hazard ratio 2.84, 95% CI 1.92–4.21), independently of each other, were associated with a higher risk of developing the composite outcome, as well as incident AMI or CKD alone after adjusting for traditional cardiovascular risk factors and diabetes-related variables. Conclusions: Our study shows that the elastographic parameters of liver steatosis and fibrosis independently predict the long-term risk of developing chronic vascular complications in T2DM patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Diabetes and its Complications
Brojčani podacivol. 36, br. 8, 108226
p-ISSN1056-8727
DOIhttps://doi.org/10.1016/j.jdiacomp.2022.108226
URN:NBNurn:nbn:hr:184:544419
Datum objave publikacije2022-08
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S1056872722001325
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-09-20 13:18:11