prikaz prve stranice dokumenta Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy
  Download
PDF 263.79 KB
Scientific paper - Original scientific paper
Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy
Biomedical Reports, 15 (2021), 6; 1-5. urn:nbn:hr:184:471732
Zečkanović, Aida; Maver, Aleš; Ristić, Smiljana; Starčević Čizmarević, Nada; Peterlin, Borut; Lovrečić, Luca

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Zečkanović, A., Maver, A., Ristić, S., Starčević Čizmarević, N., Peterlin, B. & Lovrečić, L. (2021). Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy. Biomedical Reports, 15. (6), 1-5. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:471732

Zečkanović, Aida, et al. "Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy." Biomedical Reports, vol. 15, no. 6, 2021, pp. 1-5. https://urn.nsk.hr/urn:nbn:hr:184:471732

Zečkanović, Aida, Aleš Maver, Smiljana Ristić, Nada Starčević Čizmarević, Borut Peterlin and Luca Lovrečić. "Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy." Biomedical Reports 15, no. 6 (2021): 1-5. https://urn.nsk.hr/urn:nbn:hr:184:471732

Zečkanović, A., et al. (2021) 'Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy', Biomedical Reports, 15(6), pp. 1-5. Available at: https://urn.nsk.hr/urn:nbn:hr:184:471732 (Accessed 28 April 2024)

Zečkanović A, Maver A, Ristić S, Starčević Čizmarević N, Peterlin B, Lovrečić L. Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy. Biomedical Reports [Internet]. 2021 [cited 2024 April 28];15(6):1-5. Available at: https://urn.nsk.hr/urn:nbn:hr:184:471732

A. Zečkanović, A. Maver, S. Ristić, N. Starčević Čizmarević, B. Peterlin and L. Lovrečić, "Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy", Biomedical Reports, vol. 15, no. 6, pp. 1-5, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:471732. [Accessed: 28 April 2024]

Metadata
Title (english)Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy
AuthorAida Zečkanović
AuthorAleš Maver
AuthorSmiljana Ristić
MBZ: 142283
AuthorNada Starčević Čizmarević
AuthorBorut Peterlin
AuthorLuca Lovrečić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
Pattern recognition receptors, such as specific nucleotide binding oligomerization domain protein 2, and their polymorphisms may be involved in the pathogenesis of multiple sclerosis (MS). They may also play a role in the forma tion of neutralizing antibodies against interferon β (INF β), and may exhibit lowered efficacy. Identification of these poly morphisms may be useful for early identification of potential non responders and to allow for modification of treatment regimens earlier. The differences in genotype distribution and allele frequency of the rs3135499 and rs2066842 NOD2 poly morphisms between patients with MS and healthy controls were analysed in the present study. The group of patients were divided into responders and non responders to INF β therapy to evaluate the association of both polymorphisms with response to therapy. No differences in the genotype frequencies between the responder and non responder groups were observed. However, a statistically significant difference in genotype frequencies of TT homozygotes for rs2066842 between patients with MS and healthy controls was observed (χ2 =11.8 ; P=0.003). A recessive genotype model and allele distribution in rs2066842 suggest that the genotype TT and allele T itself are protective against MS. The odds ratio of 0.12 represents an 8.33x lower risk for MS if an individual has a TT genotype. The significantly lower incidence of the TT genotype of rs2066842 in patients with MS suggests that the TT genotype and T allele may be a protective genetic factor against MS.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiomedical Reports
Numberingvol. 15, no. 6, pp. 1-5
p-ISSN2049-9434
URN:NBNurn:nbn:hr:184:471732
Publication2021
Document URLhttp://bib.irb.hr/1149298
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-01-31 09:50:49