prikaz prve stranice dokumenta Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy
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Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy
Biomedical Reports, 15 (2021), 6; 1-5. urn:nbn:hr:184:471732
Zečkanović, Aida; Maver, Aleš; Ristić, Smiljana; Starčević Čizmarević, Nada; Peterlin, Borut; Lovrečić, Luca

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Zečkanović, A., Maver, A., Ristić, S., Starčević Čizmarević, N., Peterlin, B. i Lovrečić, L. (2021). Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy. Biomedical Reports, 15. (6), 1-5. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:471732

Zečkanović, Aida, et al. "Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy." Biomedical Reports, vol. 15, br. 6, 2021, str. 1-5. https://urn.nsk.hr/urn:nbn:hr:184:471732

Zečkanović, Aida, Aleš Maver, Smiljana Ristić, Nada Starčević Čizmarević, Borut Peterlin i Luca Lovrečić. "Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy." Biomedical Reports 15, br. 6 (2021): 1-5. https://urn.nsk.hr/urn:nbn:hr:184:471732

Zečkanović, A., et al. (2021) 'Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy', Biomedical Reports, 15(6), str. 1-5. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:471732 (Datum pristupa: 24.04.2024.)

Zečkanović A, Maver A, Ristić S, Starčević Čizmarević N, Peterlin B, Lovrečić L. Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy. Biomedical Reports [Internet]. 2021. [pristupljeno 24.04.2024.];15(6):1-5. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:471732

A. Zečkanović, A. Maver, S. Ristić, N. Starčević Čizmarević, B. Peterlin i L. Lovrečić, "Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy", Biomedical Reports, vol. 15, br. 6, str. 1-5, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:471732. [Citirano: 24.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:471732
Podaci o radu
Naslov (engleski)Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy
AutorAida Zečkanović
AutorAleš Maver
AutorSmiljana Ristić
MBZ: 142283
AutorNada Starčević Čizmarević
AutorBorut Peterlin
AutorLuca Lovrečić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
Pattern recognition receptors, such as specific nucleotide binding oligomerization domain protein 2, and their polymorphisms may be involved in the pathogenesis of multiple sclerosis (MS). They may also play a role in the forma tion of neutralizing antibodies against interferon β (INF β), and may exhibit lowered efficacy. Identification of these poly morphisms may be useful for early identification of potential non responders and to allow for modification of treatment regimens earlier. The differences in genotype distribution and allele frequency of the rs3135499 and rs2066842 NOD2 poly morphisms between patients with MS and healthy controls were analysed in the present study. The group of patients were divided into responders and non responders to INF β therapy to evaluate the association of both polymorphisms with response to therapy. No differences in the genotype frequencies between the responder and non responder groups were observed. However, a statistically significant difference in genotype frequencies of TT homozygotes for rs2066842 between patients with MS and healthy controls was observed (χ2 =11.8 ; P=0.003). A recessive genotype model and allele distribution in rs2066842 suggest that the genotype TT and allele T itself are protective against MS. The odds ratio of 0.12 represents an 8.33x lower risk for MS if an individual has a TT genotype. The significantly lower incidence of the TT genotype of rs2066842 in patients with MS suggests that the TT genotype and T allele may be a protective genetic factor against MS.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedical Reports
Brojčani podacivol. 15, br. 6, str. 1-5
p-ISSN2049-9434
URN:NBNurn:nbn:hr:184:471732
Datum objave publikacije2021
URL dokumentahttp://bib.irb.hr/1149298
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2023-01-31 09:50:49