prikaz prve stranice dokumenta Significant liver fibrosis, as assessed by fibroscan, is independently associated with chronic vascular complications of type 2 diabetes: A multicenter study
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Scientific paper - Original scientific paper
Significant liver fibrosis, as assessed by fibroscan, is independently associated with chronic vascular complications of type 2 diabetes: A multicenter study
Diabetes Research and Clinical Practice, 177 (2021); 108884. https://doi.org/10.1016/j.diabres.2021.108884
Mikolašević, Ivana; Rahelić, Dario; Turk Wensween, Tamara; Ružić, Alen; Domislović, Viktor; Hauser, Goran; Matić, T.; Radić-Krišto, Delfa; Krznarić, Z.; Radić, M.; Filipec Kanižaj, Tajana; Martinović, M.; Jerkić, H.; Medjimurec, M.; Targher, G. More authors...

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Mikolašević, I., Rahelić, D., Turk Wensween, T., Ružić, A., Domislović, V., Hauser, G. ... Targher, G. (2021). Significant liver fibrosis, as assessed by fibroscan, is independently associated with chronic vascular complications of type 2 diabetes: A multicenter study. Diabetes Research and Clinical Practice, 177.. doi: 10.1016/j.diabres.2021.108884

Mikolašević, Ivana, et al. "Significant liver fibrosis, as assessed by fibroscan, is independently associated with chronic vascular complications of type 2 diabetes: A multicenter study." Diabetes Research and Clinical Practice, vol. 177, 2021. https://doi.org/10.1016/j.diabres.2021.108884

Mikolašević, Ivana, Dario Rahelić, Tamara Turk Wensween, Alen Ružić, Viktor Domislović, Goran Hauser, T. Matić, et al. "Significant liver fibrosis, as assessed by fibroscan, is independently associated with chronic vascular complications of type 2 diabetes: A multicenter study." Diabetes Research and Clinical Practice 177 (2021). https://doi.org/10.1016/j.diabres.2021.108884

Mikolašević, I., et al. (2021) 'Significant liver fibrosis, as assessed by fibroscan, is independently associated with chronic vascular complications of type 2 diabetes: A multicenter study', Diabetes Research and Clinical Practice, 177. doi: 10.1016/j.diabres.2021.108884

Mikolašević I, Rahelić D, Turk Wensween T, Ružić A, Domislović V, Hauser G, and sur.. Significant liver fibrosis, as assessed by fibroscan, is independently associated with chronic vascular complications of type 2 diabetes: A multicenter study. Diabetes Research and Clinical Practice [Internet]. 2021 July [cited 2024 May 11];177. doi: 10.1016/j.diabres.2021.108884

I. Mikolašević, et al., "Significant liver fibrosis, as assessed by fibroscan, is independently associated with chronic vascular complications of type 2 diabetes: A multicenter study", Diabetes Research and Clinical Practice, vol. 177, July 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:583907. [Accessed: 11 May 2024]

Metadata
Title (english)Significant liver fibrosis, as assessed by fibroscan, is independently associated with chronic vascular complications of type 2 diabetes: A multicenter study
AuthorIvana Mikolašević
AuthorDario Rahelić
AuthorTamara Turk Wensween
AuthorAlen Ružić
AuthorViktor Domislović
AuthorGoran Hauser
AuthorT. Matić
AuthorDelfa Radić-Krišto
AuthorZ. Krznarić
AuthorM. Radić
AuthorTajana Filipec Kanižaj
AuthorM. Martinović
AuthorH. Jerkić
AuthorM. Medjimurec
AuthorG. Targher
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aims The aim of this study was to investigate whether controlled attenuation parameter (CAP) and liver stiffness measurement (LSM), as assessed by vibration-controlled transient elastography (VCTE), are associated with chronic vascular complications of diabetes mellitus type 2 (T2DM). Methods We studied 442 outpatients with established T2DM, and who underwent VCTE and extensive assessment of chronic vascular complications of diabetes. Results A quarter of analyzed patients had a previous history of myocardial infarction and/or ischemic stroke, and about half of them had at least one microvascular complication (chronic kidney disease (CKD), retinopathy or polyneuropathy). The prevalence of liver steatosis (i.e., CAP ≥ 238 dB/m) and significant liver fibrosis (i.e., LSM ≥ 7.0/6.2 kPa) was 84.2% and 46.6%, respectively. Significant liver fibrosis was associated with an increased likelihood of having myocardial infarction (adjusted-odds ratio 6.61, 95%CI 1.66– 37.4), peripheral polyneuropathy (adjusted-OR 4.55, 95%CI 1.25–16.6), CKD (adjusted-OR 4.54, 95%CI 1.24–16.6) or retinopathy (adjusted-OR 1.81, 95%CI 1.62–1.97), independently of cardiometabolic risk factors, diabetes-related variables, and other potential confounders. Liver steatosis was not independently associated with any macro-/microvascular diabetic complications. Conclusions Significant liver fibrosis is strongly associated with the presence of macro-/microvascular complications in patients with T2DM. These results offer a new perspective on the follow-up of people with T2DM.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiabetes Research and Clinical Practice
Numberingvol. 177, 108884
p-ISSN0168-8227
DOIhttps://doi.org/10.1016/j.diabres.2021.108884
URN:NBNurn:nbn:hr:184:583907
Publication2021-07
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0168822721002448
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2023-02-02 09:27:37