prikaz prve stranice dokumenta Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice
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Scientific paper - Original scientific paper
Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice
International journal of molecular sciences, 22 (2021), 12; 6584. https://doi.org/10.3390/ijms22126584
Pilipović, Kristina; Rajič Bumber, Jelena; Dolenec, Petra; Gržeta, Nika; Janković, Tamara; Križ, Jasna; Župan, Gordana

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Pilipović, K., Rajič Bumber, J., Dolenec, P., Gržeta, N., Janković, T., Križ, J. & Župan, G. (2021). Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice. International journal of molecular sciences, 22. (12). doi: 10.3390/ijms22126584

Pilipović, Kristina, et al. "Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice." International journal of molecular sciences, vol. 22, no. 12, 2021. https://doi.org/10.3390/ijms22126584

Pilipović, Kristina, Jelena Rajič Bumber, Petra Dolenec, Nika Gržeta, Tamara Janković, Jasna Križ and Gordana Župan. "Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice." International journal of molecular sciences 22, no. 12 (2021). https://doi.org/10.3390/ijms22126584

Pilipović, K., et al. (2021) 'Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice', International journal of molecular sciences, 22(12). doi: 10.3390/ijms22126584

Pilipović K, Rajič Bumber J, Dolenec P, Gržeta N, Janković T, Križ J, and sur.. Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice. International journal of molecular sciences [Internet]. 2021 [cited 2024 November 26];22(12). doi: 10.3390/ijms22126584

K. Pilipović, et al., "Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice", International journal of molecular sciences, vol. 22, no. 12, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:076270. [Accessed: 26 November 2024]

Metadata
Title (english)Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice
AuthorKristina Pilipović
AuthorJelena Rajič Bumber
AuthorPetra Dolenec
AuthorNika Gržeta
AuthorTamara Janković
AuthorJasna Križ
MBZ: 201556
AuthorGordana Župan
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Little is known about the impairments and pathological changes in the visual system in mild brain trauma, especially repetitive mild traumatic brain injury (mTBI). The goal of this study was to examine and compare the effects of repeated head impacts on the neurodegeneration, axonal integrity, and glial activity in the optic tract (OT), as well as on neuronal preservation, glial responses, and synaptic organization in the lateral geniculate nucleus (LGN) and superior colliculus (SC), in wild-type mice and transgenic animals with overexpression of human TDP-43 mutant protein (TDP-43G348C) at 6 months after repeated closed head traumas. Animals were also assessed in the Barnes maze (BM) task. Neurodegeneration, axonal injury, and gliosis were detected in the OT of the injured animals of both genotypes. In the traumatized mice, myelination of surviving axons was mostly preserved, and the expression of neurofilament light chain was unaffected. Repetitive mTBI did not induce changes in the LGN and the SC, nor did it affect the performance of the BM task in the traumatized wild-type and TDP-43 transgenic mice. Differences in neuropathological and behavioral assessments between the injured wild-type and TDP-43G348C mice were not revealed. Results of the current study suggest that repetitive mTBI was associated with chronic damage and inflammation in the OT in wild-type and TDP-43G348C mice, which were not accompanied with behavioral problems and were not affected by the TDP-43 genotype, while the LGN and the SC remained preserved in the used experimental conditions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational journal of molecular sciences
Numberingvol. 22, no. 12, 6584
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms22126584
URN:NBNurn:nbn:hr:184:076270
Publication2021
Document URLhttp://bib.irb.hr/1138226
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-02-15 09:19:05