prikaz prve stranice dokumenta Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice
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Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice
International journal of molecular sciences, 22 (2021), 12; 6584. https://doi.org/10.3390/ijms22126584
Pilipović, Kristina; Rajič Bumber, Jelena; Dolenec, Petra; Gržeta, Nika; Janković, Tamara; Križ, Jasna; Župan, Gordana

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Pilipović, K., Rajič Bumber, J., Dolenec, P., Gržeta, N., Janković, T., Križ, J. i Župan, G. (2021). Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice. International journal of molecular sciences, 22. (12). doi: 10.3390/ijms22126584

Pilipović, Kristina, et al. "Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice." International journal of molecular sciences, vol. 22, br. 12, 2021. https://doi.org/10.3390/ijms22126584

Pilipović, Kristina, Jelena Rajič Bumber, Petra Dolenec, Nika Gržeta, Tamara Janković, Jasna Križ i Gordana Župan. "Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice." International journal of molecular sciences 22, br. 12 (2021). https://doi.org/10.3390/ijms22126584

Pilipović, K., et al. (2021) 'Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice', International journal of molecular sciences, 22(12). doi: 10.3390/ijms22126584

Pilipović K, Rajič Bumber J, Dolenec P, Gržeta N, Janković T, Križ J, i sur.. Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice. International journal of molecular sciences [Internet]. 2021. [pristupljeno 26.11.2024.];22(12). doi: 10.3390/ijms22126584

K. Pilipović, et al., "Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice", International journal of molecular sciences, vol. 22, br. 12, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:076270. [Citirano: 26.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:076270
Podaci o radu
Naslov (engleski)Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice
AutorKristina Pilipović
AutorJelena Rajič Bumber
AutorPetra Dolenec
AutorNika Gržeta
AutorTamara Janković
AutorJasna Križ
MBZ: 201556
AutorGordana Župan
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za farmakologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Little is known about the impairments and pathological changes in the visual system in mild brain trauma, especially repetitive mild traumatic brain injury (mTBI). The goal of this study was to examine and compare the effects of repeated head impacts on the neurodegeneration, axonal integrity, and glial activity in the optic tract (OT), as well as on neuronal preservation, glial responses, and synaptic organization in the lateral geniculate nucleus (LGN) and superior colliculus (SC), in wild-type mice and transgenic animals with overexpression of human TDP-43 mutant protein (TDP-43G348C) at 6 months after repeated closed head traumas. Animals were also assessed in the Barnes maze (BM) task. Neurodegeneration, axonal injury, and gliosis were detected in the OT of the injured animals of both genotypes. In the traumatized mice, myelination of surviving axons was mostly preserved, and the expression of neurofilament light chain was unaffected. Repetitive mTBI did not induce changes in the LGN and the SC, nor did it affect the performance of the BM task in the traumatized wild-type and TDP-43 transgenic mice. Differences in neuropathological and behavioral assessments between the injured wild-type and TDP-43G348C mice were not revealed. Results of the current study suggest that repetitive mTBI was associated with chronic damage and inflammation in the OT in wild-type and TDP-43G348C mice, which were not accompanied with behavioral problems and were not affected by the TDP-43 genotype, while the LGN and the SC remained preserved in the used experimental conditions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational journal of molecular sciences
Brojčani podacivol. 22, br. 12, 6584
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms22126584
URN:NBNurn:nbn:hr:184:076270
Datum objave publikacije2021
URL dokumentahttp://bib.irb.hr/1138226
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-02-15 09:19:05