prikaz prve stranice dokumenta Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?
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Scientific paper - Original scientific paper
Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?
Medical hypotheses, 79 (2012), 5; 592-594. https://doi.org/10.1016/j.mehy.2012.07.026
Laškarin, Gordana; Peršić, Viktor; Miškulin, Rajko; Ružić, Alen; Zaputović, Luka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Laškarin, G., Peršić, V., Miškulin, R., Ružić, A. & Zaputović, L. (2012). Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?. Medical hypotheses, 79. (5), 592-594. doi: 10.1016/j.mehy.2012.07.026

Laškarin, Gordana, et al. "Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?." Medical hypotheses, vol. 79, no. 5, 2012, pp. 592-594. https://doi.org/10.1016/j.mehy.2012.07.026

Laškarin, Gordana, Viktor Peršić, Rajko Miškulin, Alen Ružić and Luka Zaputović. "Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?." Medical hypotheses 79, no. 5 (2012): 592-594. https://doi.org/10.1016/j.mehy.2012.07.026

Laškarin, G., et al. (2012) 'Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?', Medical hypotheses, 79(5), pp. 592-594. doi: 10.1016/j.mehy.2012.07.026

Laškarin G, Peršić V, Miškulin R, Ružić A, Zaputović L. Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?. Medical hypotheses [Internet]. 2012 [cited 2025 February 17];79(5):592-594. doi: 10.1016/j.mehy.2012.07.026

G. Laškarin, V. Peršić, R. Miškulin, A. Ružić and L. Zaputović, "Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?", Medical hypotheses, vol. 79, no. 5, pp. 592-594, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:392697. [Accessed: 17 February 2025]

Metadata
Title (english)Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?
AuthorGordana Laškarin
AuthorViktor Peršić
AuthorRajko Miškulin
AuthorAlen Ružić
AuthorLuka Zaputović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Rehabilitatiom Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Heat shock proteins (HSPs) have changed very little with evolution, suggesting that they play important role(s) in cellular survival. Specifically, HSPs protect cells from induced cell death. Their expression is triggered by heat or other stress, such as ischemia. HSPs provide protection against protein denaturation, although they slightly differ with respect to group affiliation. Release of HSPs from necrotic and ischemic cardiomyocytes into the intercellular space and plasma may correlate with the intensity of the proinflammatory response observed during and immediately after myocardial infarction. We hypothesized that the plasma concentration of particularly inducible forms of HSPs from different groups (HSP 90, HSP 70, HSP 60 and/or HSP 20) can be used as early specific markers for diagnosing myocardial infarction in patients with acute coronary syndrome. Our hypothesis is supported by the following data: (I) HSP expression occurs very early after acute coronary events ; (II) HSP concentrations increase rapidly in the peripheral blood ; (III) HSP concentrations correlate with markers of myocardial necrosis and proinflammatory biochemical parameters. The magnitude of the increase in plasma HSP concentrations over initial concentrations during the period of highest sensitivity and specificity of the assay could be important for early detection of myocardial infarction and distinguishing it from unstable angina. We suggest that these parameters, along with close observation of patients with chest pain, will assist providers who must differentiate between acute myocardial damage and other organ diseases.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical hypotheses
Numberingvol. 79, no. 5, pp. 592-594
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2012.07.026
URN:NBNurn:nbn:hr:184:392697
Publication2012
ProjectNumber: 062-0620402-0377
Title (croatian): Imunoregulacijske funkcije antigen predočnih stanica tijekom rane trudnoće
Title (english): Immunoregulatory functions of antigen presenting cells in early pregnancy
Leader: Gordana Laškarin
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-1081875-0545
Title (croatian): Aterogeneza i trombogeneza u ishemijskoj bolesti srca
Title (english): Atherogenesis and thrombogenesis in ischemic heart disease
Leader: Luka Zaputović
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/603718
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2023-04-11 09:23:13