prikaz prve stranice dokumenta Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?
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Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?
Medical hypotheses, 79 (2012), 5; 592-594. https://doi.org/10.1016/j.mehy.2012.07.026
Laškarin, Gordana; Peršić, Viktor; Miškulin, Rajko; Ružić, Alen; Zaputović, Luka

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Laškarin, G., Peršić, V., Miškulin, R., Ružić, A. i Zaputović, L. (2012). Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?. Medical hypotheses, 79. (5), 592-594. doi: 10.1016/j.mehy.2012.07.026

Laškarin, Gordana, et al. "Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?." Medical hypotheses, vol. 79, br. 5, 2012, str. 592-594. https://doi.org/10.1016/j.mehy.2012.07.026

Laškarin, Gordana, Viktor Peršić, Rajko Miškulin, Alen Ružić i Luka Zaputović. "Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?." Medical hypotheses 79, br. 5 (2012): 592-594. https://doi.org/10.1016/j.mehy.2012.07.026

Laškarin, G., et al. (2012) 'Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?', Medical hypotheses, 79(5), str. 592-594. doi: 10.1016/j.mehy.2012.07.026

Laškarin G, Peršić V, Miškulin R, Ružić A, Zaputović L. Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?. Medical hypotheses [Internet]. 2012. [pristupljeno 06.11.2024.];79(5):592-594. doi: 10.1016/j.mehy.2012.07.026

G. Laškarin, V. Peršić, R. Miškulin, A. Ružić i L. Zaputović, "Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?", Medical hypotheses, vol. 79, br. 5, str. 592-594, 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:392697. [Citirano: 06.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:392697
Podaci o radu
Naslov (engleski)Can we assess an acute myocardial infarction in patients with acute coronary syndrome according to diagnostic accuracy of heat shock proteins?
AutorGordana Laškarin
AutorViktor Peršić
AutorRajko Miškulin
AutorAlen Ružić
AutorLuka Zaputović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za rehabilitacijsku i sportsku medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Heat shock proteins (HSPs) have changed very little with evolution, suggesting that they play important role(s) in cellular survival. Specifically, HSPs protect cells from induced cell death. Their expression is triggered by heat or other stress, such as ischemia. HSPs provide protection against protein denaturation, although they slightly differ with respect to group affiliation. Release of HSPs from necrotic and ischemic cardiomyocytes into the intercellular space and plasma may correlate with the intensity of the proinflammatory response observed during and immediately after myocardial infarction. We hypothesized that the plasma concentration of particularly inducible forms of HSPs from different groups (HSP 90, HSP 70, HSP 60 and/or HSP 20) can be used as early specific markers for diagnosing myocardial infarction in patients with acute coronary syndrome. Our hypothesis is supported by the following data: (I) HSP expression occurs very early after acute coronary events ; (II) HSP concentrations increase rapidly in the peripheral blood ; (III) HSP concentrations correlate with markers of myocardial necrosis and proinflammatory biochemical parameters. The magnitude of the increase in plasma HSP concentrations over initial concentrations during the period of highest sensitivity and specificity of the assay could be important for early detection of myocardial infarction and distinguishing it from unstable angina. We suggest that these parameters, along with close observation of patients with chest pain, will assist providers who must differentiate between acute myocardial damage and other organ diseases.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical hypotheses
Brojčani podacivol. 79, br. 5, str. 592-594
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2012.07.026
URN:NBNurn:nbn:hr:184:392697
Datum objave publikacije2012
ProjektŠifra: 062-0620402-0377
Naziv (hrvatski): Imunoregulacijske funkcije antigen predočnih stanica tijekom rane trudnoće
Naziv (engleski): Immunoregulatory functions of antigen presenting cells in early pregnancy
Voditelj: Gordana Laškarin
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-1081875-0545
Naziv (hrvatski): Aterogeneza i trombogeneza u ishemijskoj bolesti srca
Naziv (engleski): Atherogenesis and thrombogenesis in ischemic heart disease
Voditelj: Luka Zaputović
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/603718
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-04-11 09:23:13