prikaz prve stranice dokumenta Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma
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Scientific paper - Original scientific paper
Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma
Journal of Cancer Research and Clinical Oncology, 131 (2005), 7; 453-458. https://doi.org/10.1007/s00432-004-0667-3
Valković, Toni; Fučkar, Dora; Štifter, Sanja; Matušan, Koviljka; Hasan, Milena; Dobrila, Fran; Jonjić, Nives

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Cite this document

Valković, T., Fučkar, D., Štifter, S., Matušan, K., Hasan, M., Dobrila, F. & Jonjić, N. (2005). Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma. Journal of Cancer Research and Clinical Oncology, 131. (7), 453-458. doi: 10.1007/s00432-004-0667-3

Valković, Toni, et al. "Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma." Journal of Cancer Research and Clinical Oncology, vol. 131, no. 7, 2005, pp. 453-458. https://doi.org/10.1007/s00432-004-0667-3

Valković, Toni, Dora Fučkar, Sanja Štifter, Koviljka Matušan, Milena Hasan, Fran Dobrila and Nives Jonjić. "Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma." Journal of Cancer Research and Clinical Oncology 131, no. 7 (2005): 453-458. https://doi.org/10.1007/s00432-004-0667-3

Valković, T., et al. (2005) 'Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma', Journal of Cancer Research and Clinical Oncology, 131(7), pp. 453-458. doi: 10.1007/s00432-004-0667-3

Valković T, Fučkar D, Štifter S, Matušan K, Hasan M, Dobrila F, and sur.. Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma. Journal of Cancer Research and Clinical Oncology [Internet]. 2005 [cited 2024 April 29];131(7):453-458. doi: 10.1007/s00432-004-0667-3

T. Valković, et al., "Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma", Journal of Cancer Research and Clinical Oncology, vol. 131, no. 7, pp. 453-458, 2005. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:368284. [Accessed: 29 April 2024]

Metadata
Title (english)Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma
AuthorToni Valković
AuthorDora Fučkar
AuthorSanja Štifter
AuthorKoviljka Matušan
AuthorMilena Hasan
AuthorFran Dobrila
AuthorNives Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Purpose and method: Monocyte chemotactic protein-1 (MCP-1) is a chemokine involved in the macrophage infiltration of tumor tissue. Tumor-associated macrophages (TAMs) are a population of mononuclear phagocytic cells that can have a complex function in tumor biology. The aim of this study was to determine the possible correlation between parenchymal MCP-1 expression and TAM level by immunohistochemical analysis of 97 invasive ductal breast carcinomas, not otherwise specified (NOS), and to investigate their relation with tumor size, histological grade, mitotic activity index (MAI) and lymph node status. Secondly, the MCP-1 mRNA was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) in eight samples of normal breast tissue and 27 samples of invasive breast carcinomas and compared with TAMs. Results: MCP-1 immunoreactivity was present in tumor cells (17/97), but also in TAMs, fibroblasts and endothelial cells. The statistical analysis did not show a significant correlation between MCP-1 expression in tumoral epithelium and tumor size, histological grade, MAI, lymph node status or TAMs. The results of RT-PCR showed that, in all cases of breast carcinomas (27/27) and the majority of normal breast tissues (7/8), the number of detected MCP-1 cDNA copies was above the detection limit. However, carcinomas showed higher levels of MCP-1 mRNA than normal breast tissue. Nevertheless, the statistical analysis did not find a significant correlation between MCP-1 expression and macrophage infiltrations. Conclusion: These results indicate that MCP-1 is probably not the only and/or crucial factor involved in macrophage attraction to tumor locus in breast carcinoma.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Cancer Research and Clinical Oncology
Numberingvol. 131, no. 7, pp. 453-458
p-ISSN0171-5216
e-ISSN1432-1335
DOIhttps://doi.org/10.1007/s00432-004-0667-3
URN:NBNurn:nbn:hr:184:368284
Publication2005
Document URLhttp://link.springer.com/10.1007/s00432-004-0667-3
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-05-18 12:01:14