prikaz prve stranice dokumenta Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma
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Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma
Journal of Cancer Research and Clinical Oncology, 131 (2005), 7; 453-458. https://doi.org/10.1007/s00432-004-0667-3
Valković, Toni; Fučkar, Dora; Štifter, Sanja; Matušan, Koviljka; Hasan, Milena; Dobrila, Fran; Jonjić, Nives

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Valković, T., Fučkar, D., Štifter, S., Matušan, K., Hasan, M., Dobrila, F. i Jonjić, N. (2005). Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma. Journal of Cancer Research and Clinical Oncology, 131. (7), 453-458. doi: 10.1007/s00432-004-0667-3

Valković, Toni, et al. "Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma." Journal of Cancer Research and Clinical Oncology, vol. 131, br. 7, 2005, str. 453-458. https://doi.org/10.1007/s00432-004-0667-3

Valković, Toni, Dora Fučkar, Sanja Štifter, Koviljka Matušan, Milena Hasan, Fran Dobrila i Nives Jonjić. "Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma." Journal of Cancer Research and Clinical Oncology 131, br. 7 (2005): 453-458. https://doi.org/10.1007/s00432-004-0667-3

Valković, T., et al. (2005) 'Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma', Journal of Cancer Research and Clinical Oncology, 131(7), str. 453-458. doi: 10.1007/s00432-004-0667-3

Valković T, Fučkar D, Štifter S, Matušan K, Hasan M, Dobrila F, i sur.. Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma. Journal of Cancer Research and Clinical Oncology [Internet]. 2005. [pristupljeno 05.05.2024.];131(7):453-458. doi: 10.1007/s00432-004-0667-3

T. Valković, et al., "Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma", Journal of Cancer Research and Clinical Oncology, vol. 131, br. 7, str. 453-458, 2005. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:368284. [Citirano: 05.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:368284
Podaci o radu
Naslov (engleski)Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma
AutorToni Valković
AutorDora Fučkar
AutorSanja Štifter
AutorKoviljka Matušan
AutorMilena Hasan
AutorFran Dobrila
AutorNives Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kirurgiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Purpose and method: Monocyte chemotactic protein-1 (MCP-1) is a chemokine involved in the macrophage infiltration of tumor tissue. Tumor-associated macrophages (TAMs) are a population of mononuclear phagocytic cells that can have a complex function in tumor biology. The aim of this study was to determine the possible correlation between parenchymal MCP-1 expression and TAM level by immunohistochemical analysis of 97 invasive ductal breast carcinomas, not otherwise specified (NOS), and to investigate their relation with tumor size, histological grade, mitotic activity index (MAI) and lymph node status. Secondly, the MCP-1 mRNA was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) in eight samples of normal breast tissue and 27 samples of invasive breast carcinomas and compared with TAMs. Results: MCP-1 immunoreactivity was present in tumor cells (17/97), but also in TAMs, fibroblasts and endothelial cells. The statistical analysis did not show a significant correlation between MCP-1 expression in tumoral epithelium and tumor size, histological grade, MAI, lymph node status or TAMs. The results of RT-PCR showed that, in all cases of breast carcinomas (27/27) and the majority of normal breast tissues (7/8), the number of detected MCP-1 cDNA copies was above the detection limit. However, carcinomas showed higher levels of MCP-1 mRNA than normal breast tissue. Nevertheless, the statistical analysis did not find a significant correlation between MCP-1 expression and macrophage infiltrations. Conclusion: These results indicate that MCP-1 is probably not the only and/or crucial factor involved in macrophage attraction to tumor locus in breast carcinoma.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Cancer Research and Clinical Oncology
Brojčani podacivol. 131, br. 7, str. 453-458
p-ISSN0171-5216
e-ISSN1432-1335
DOIhttps://doi.org/10.1007/s00432-004-0667-3
URN:NBNurn:nbn:hr:184:368284
Datum objave publikacije2005
URL dokumentahttp://link.springer.com/10.1007/s00432-004-0667-3
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-05-18 12:01:14