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master's thesis
Dijabetička bolest bubrega: dijagnostika i liječenje
diplomski rad
Rijeka: University of Rijeka, Faculty of Medicine, 2023. urn:nbn:hr:184:486927
Nikpalj, Lorena
University of Rijeka
Faculty of Medicine
Department of Internal Medicine

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Nikpalj, L. (2023). Dijabetička bolest bubrega: dijagnostika i liječenje : diplomski rad (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:486927

Nikpalj, Lorena. "Dijabetička bolest bubrega: dijagnostika i liječenje : diplomski rad." Master's thesis, University of Rijeka, Faculty of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:184:486927

Nikpalj, Lorena. "Dijabetička bolest bubrega: dijagnostika i liječenje : diplomski rad." Master's thesis, University of Rijeka, Faculty of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:184:486927

Nikpalj, L. (2023). 'Dijabetička bolest bubrega: dijagnostika i liječenje : diplomski rad', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 27 November 2024, https://urn.nsk.hr/urn:nbn:hr:184:486927

Nikpalj L. Dijabetička bolest bubrega: dijagnostika i liječenje : diplomski rad [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2023 [cited 2024 November 27] Available at: https://urn.nsk.hr/urn:nbn:hr:184:486927

L. Nikpalj, "Dijabetička bolest bubrega: dijagnostika i liječenje : diplomski rad", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:184:486927

Metadata
TitleDijabetička bolest bubrega: dijagnostika i liječenje : diplomski rad
Title (english)Diabetic kidney disease: diagnosis and treatment
AuthorLorena Nikpalj
MentorSanja Klobučar-Majanović (mentor)
Committee memberIvan Bubić (predsjednik povjerenstva)
Committee memberVanja Licul (član povjerenstva)
Committee memberDijana Detel (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Rijeka
Defense date and country2023-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Dijabetes melitus predstavlja kompleksni, kronični poremećaj koji sa sobom nosi čitav niz komplikacija te predstavlja vodeći javnozdravstveni izazov 21. stoljeća, s obzirom na nepovoljnu epidemiološku statistiku s rastućom prevalencijom i povećanim stopama morbiditeta i mortaliteta među svjetskim stanovništvom. DBB predstavlja najčešću mikrovaskularnu komplikaciju DM-a. Dijabetes je odgovoran za preko 40% novih slučajeva razvoja ESRD-a te kao takav predstavlja vodeći faktor razvoja KBB-a. Dijabetičku bolest bubrega obilježava prisutnost KBB-a (s perzistentnom albuminurijom i/ili trajnim smanjenjem glomerularne filtracije) u trajanju od najmanje tri mjeseca, u osoba oboljelih od dijabetesa. Pri tom, iznimno je važno prepoznati potencijalne čimbenike rizika, kako u svrhu prevencije i odgađanja daljnje progresije, tako i u svrhu liječenja DBB-a. Složeni metabolički mehanizmi uključeni u patogenezu DBB-a obuhvaćaju hiperglikemiju uz stvaranje završnih produkata glikacije, glomerularnu hiperfiltraciju, ishemiju, hipoksiju, ekspresiju raznih citokina, stvaranje slobodnih radikala kisika te brojne druge koji se još istražuju. Dijagnoza DBB-a se postavlja klinički, odnosno mjerenjem albuminurije i glomerularne filtracije, dok se u nejasnim slučajevima izvodi biopsija bubrega. Glavne strategije liječenja DBB-a su regulacija glikemije i kontrola krvnog tlaka. Antihiperglikemici iz skupine SGLT-2 inhibitora, posebice dapagliflozin i empagliflozin, zahvaljujući dokazanim renoprotektivnim svojstvima, iskazuju izniman terapijski potencijal sa svrhom sprječavanja daljnje progresije KBB-a. Zahvaljujući poboljšanoj skrbi i liječenju, prognoza pacijenata oboljelih od DBB-a se znatno poboljšala, no i dalje se traga za inovativnijim strategijama u vidu prevencije, dijagnostike i liječenja DBB-a.
Abstract (english)
Diabetes mellitus is a complex chronic disease that involves a whole range of complications and represents the leading public health challenge of the 21st century, given the unfavorable epidemiological statistics of rising prevalence and increased morbidity and mortality rates in the world population. Diabetic kidney disease is the most common microvascular complication of DM. Diabetes accounts for more than 40% of new cases of ESRD, making it the most important factor in the development of CKD. Diabetic kidney disease is characterized by the presence of CKD (with persistent albuminuria and/or a permanent reduction in glomerular filtration rate) lasting at least three months in diabetic patients. At the same time, it is extremely important to identify potential risk factors, both to prevent and delay further progression and to treat CKD. The complex metabolic mechanisms involved in the pathogenesis of DKK include hyperglycemia with formation of glycation end products, glomerular hyperfiltration, ischemia, hypoxia, expression of various cytokines, reactive oxygen species, and many others that are still being explored. DKK is diagnosed clinically by measuring albuminuria and glomerular filtration, while renal biopsy is performed in uncertain cases. Key treatment strategies for DKK include glycemic and blood pressure control. Antihyperglycemic agents from the group of SGLT-2 inhibitors, particularly dapagliflozin and empagliflozin, have extraordinary therapeutic potential to prevent further progression of CKD due to their proven renoprotective effects. Thanks to improved care and treatment, the prognosis of DKK patients has improved significantly, but further innovative strategies for the prevention, diagnosis and treatment of DKK are still being sought.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:486927
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-06-30 12:12:27