prikaz prve stranice dokumenta Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways
No public access
Scientific paper - Original scientific paper
Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways
Food and Chemical Toxicology, 171 (2023); 113538. https://doi.org/10.1016/j.fct.2022.113538
Potočnjak, Iva; Šimić, Lidija; Batičić, Lara; Križan, Hrvoje; Domitrović, Robert

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Potočnjak, I., Šimić, L., Batičić, L., Križan, H. & Domitrović, R. (2023). Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways. Food and Chemical Toxicology, 171.. doi: 10.1016/j.fct.2022.113538

Potočnjak, Iva, et al. "Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways." Food and Chemical Toxicology, vol. 171, 2023. https://doi.org/10.1016/j.fct.2022.113538

Potočnjak, Iva, Lidija Šimić, Lara Batičić, Hrvoje Križan and Robert Domitrović. "Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways." Food and Chemical Toxicology 171 (2023). https://doi.org/10.1016/j.fct.2022.113538

Potočnjak, I., et al. (2023) 'Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways', Food and Chemical Toxicology, 171. doi: 10.1016/j.fct.2022.113538

Potočnjak I, Šimić L, Batičić L, Križan H, Domitrović R. Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways. Food and Chemical Toxicology [Internet]. 2023 January 01 [cited 2024 July 07];171. doi: 10.1016/j.fct.2022.113538

I. Potočnjak, L. Šimić, L. Batičić, H. Križan and R. Domitrović, "Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways", Food and Chemical Toxicology, vol. 171, January 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:916634. [Accessed: 07 July 2024]

Metadata
Title (english)Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways
AuthorIva Potočnjak
AuthorLidija Šimić
AuthorLara Batičić
AuthorHrvoje Križan
AuthorRobert Domitrović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Abstract (english)
Sinomenine is a pharmacologically active alkaloid with antioxidant and anti-inflammatory properties. We aimed to investigate the mechanism of renoprotective activity of sinomenine in kidney injury induced by cisplatin (CP). Sinomenine (5 mg/kg) was administered to mice orally in two doses, the second day after intraperitoneal application of CP (13 mg/kg). Sinomenine ameliorated kidney injury and decreased serum levels of urea and creatinine and renal expression of NGAL and KIM-1. The increase in HO-1, 4-HNE, 3-NT and TNF-α renal expression was mitigated by sinomenine. Additionally, sinomenine reduced the expression of p21, Bax, Noxa, caspase-3 and -8 and PARP1 cleavage in mice kidneys as well as the number of TUNEL-positive cells. Sinomenine attenuated CP-induced activation of ERK1/2, Akt, FOXO3a, STAT3 and NF-κB and restored Sirtuin 6 expression. In the human proximal tubular cell line HK2, sinomenine 100 μM reduced the toxic effect of CP 30 μM. Our current findings suggest that sinomenine suppresses CP-induced oxidative stress, inflammation and apoptosis in mice kidneys by targeting multiple signaling pathways.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFood and Chemical Toxicology
Numberingvol. 171, 113538
p-ISSN0278-6915
DOIhttps://doi.org/10.1016/j.fct.2022.113538
URN:NBNurn:nbn:hr:184:916634
Publication2023-01-01
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0278691522007360
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Public noteAvailable online 28 November 2022, Version of Record 12 December 2022.
Created on2023-08-29 09:15:38