prikaz prve stranice dokumenta Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways
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Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways
Food and Chemical Toxicology, 171 (2023); 113538. https://doi.org/10.1016/j.fct.2022.113538
Potočnjak, Iva; Šimić, Lidija; Batičić, Lara; Križan, Hrvoje; Domitrović, Robert

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Potočnjak, I., Šimić, L., Batičić, L., Križan, H. i Domitrović, R. (2023). Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways. Food and Chemical Toxicology, 171.. doi: 10.1016/j.fct.2022.113538

Potočnjak, Iva, et al. "Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways." Food and Chemical Toxicology, vol. 171, 2023. https://doi.org/10.1016/j.fct.2022.113538

Potočnjak, Iva, Lidija Šimić, Lara Batičić, Hrvoje Križan i Robert Domitrović. "Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways." Food and Chemical Toxicology 171 (2023). https://doi.org/10.1016/j.fct.2022.113538

Potočnjak, I., et al. (2023) 'Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways', Food and Chemical Toxicology, 171. doi: 10.1016/j.fct.2022.113538

Potočnjak I, Šimić L, Batičić L, Križan H, Domitrović R. Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways. Food and Chemical Toxicology [Internet]. 01.01.2023. [pristupljeno 28.12.2024.];171. doi: 10.1016/j.fct.2022.113538

I. Potočnjak, L. Šimić, L. Batičić, H. Križan i R. Domitrović, "Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways", Food and Chemical Toxicology, vol. 171, Siječanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:916634. [Citirano: 28.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:916634
Podaci o radu
Naslov (engleski)Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways
AutorIva Potočnjak
AutorLidija Šimić
AutorLara Batičić
AutorHrvoje Križan
AutorRobert Domitrović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Medicinska biokemija
Sažetak (engleski)
Sinomenine is a pharmacologically active alkaloid with antioxidant and anti-inflammatory properties. We aimed to investigate the mechanism of renoprotective activity of sinomenine in kidney injury induced by cisplatin (CP). Sinomenine (5 mg/kg) was administered to mice orally in two doses, the second day after intraperitoneal application of CP (13 mg/kg). Sinomenine ameliorated kidney injury and decreased serum levels of urea and creatinine and renal expression of NGAL and KIM-1. The increase in HO-1, 4-HNE, 3-NT and TNF-α renal expression was mitigated by sinomenine. Additionally, sinomenine reduced the expression of p21, Bax, Noxa, caspase-3 and -8 and PARP1 cleavage in mice kidneys as well as the number of TUNEL-positive cells. Sinomenine attenuated CP-induced activation of ERK1/2, Akt, FOXO3a, STAT3 and NF-κB and restored Sirtuin 6 expression. In the human proximal tubular cell line HK2, sinomenine 100 μM reduced the toxic effect of CP 30 μM. Our current findings suggest that sinomenine suppresses CP-induced oxidative stress, inflammation and apoptosis in mice kidneys by targeting multiple signaling pathways.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFood and Chemical Toxicology
Brojčani podacivol. 171, 113538
p-ISSN0278-6915
DOIhttps://doi.org/10.1016/j.fct.2022.113538
URN:NBNurn:nbn:hr:184:916634
Datum objave publikacije2023-01-01
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0278691522007360
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Javna napomenaAvailable online 28 November 2022, Version of Record 12 December 2022.
Datum i vrijeme pohrane2023-08-29 09:15:38