prikaz prve stranice dokumenta Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency
  Download
PDF 283.36 KB
Scientific paper - Original scientific paper
Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency
International Journal of Molecular Sciences, 24 (2023), 17; 13498. https://doi.org/10.3390/ijms241713498
Matišić, Vid; Brlek, Petar; Bulić, Luka; Molnar, Vilim; Dasović, Marina; Primorac, Dragan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Matišić, V., Brlek, P., Bulić, L., Molnar, V., Dasović, M. & Primorac, D. (2023). Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency. International Journal of Molecular Sciences, 24. (17), 13498. doi: 10.3390/ijms241713498

Matišić, Vid, et al. "Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency." International Journal of Molecular Sciences, vol. 24, no. 17, 2023, pp. 13498. https://doi.org/10.3390/ijms241713498

Matišić, Vid, Petar Brlek, Luka Bulić, Vilim Molnar, Marina Dasović and Dragan Primorac. "Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency." International Journal of Molecular Sciences 24, no. 17 (2023): 13498. https://doi.org/10.3390/ijms241713498

Matišić, V., et al. (2023) 'Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency', International Journal of Molecular Sciences, 24(17), pp. 13498. doi: 10.3390/ijms241713498

Matišić V, Brlek P, Bulić L, Molnar V, Dasović M, Primorac D. Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency. International Journal of Molecular Sciences [Internet]. 2023 August 31 [cited 2024 May 18];24(17):13498. doi: 10.3390/ijms241713498

V. Matišić, P. Brlek, L. Bulić, V. Molnar, M. Dasović and D. Primorac, "Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency", International Journal of Molecular Sciences, vol. 24, no. 17, pp. 13498, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:016710. [Accessed: 18 May 2024]

Metadata
Title (english)Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency
AuthorVid Matišić
AuthorPetar Brlek
AuthorLuka Bulić
AuthorVilim Molnar
AuthorMarina Dasović
AuthorDragan Primorac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Background: Adverse drug reactions (ADRs) are a significant cause of mortality, and pharmacogenomics (PGx) offers the potential to optimize therapeutic efficacy while minimizing ADRs. However, there is a lack of data on the Croatian population, highlighting the need for investigating the most common alleles, genotypes, and phenotypes to establish national guidelines for drug use. Methods: A single-center retrospective cross-sectional study was performed to examine the allele, genotype, and phenotype frequencies of drug-metabolizing enzymes, receptors, and other proteins in a random sample of 522 patients from Croatia using a 28-gene PGx panel. Results: Allele frequencies, genotypes, and phenotypes for the investigated genes were determined. No statistically significant differences were found between the Croatian and European populations for most analyzed genes. The most common genotypes observed in the patients resulted in normal metabolism rates. However, some genes showed higher frequencies of altered metabolism rates. Conclusions: This study provides insights into the allele, genotype, and phenotype frequencies of drug-metabolizing enzymes, receptors, and other associated proteins in the Croatian population. The findings contribute to optimizing drug use guidelines, potentially reducing ADRs, and improving therapeutic efficacy. Further research is needed to tailor population-specific interventions based on these findings and their long-term benefits.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 17, p. 13498, 13498
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms241713498
URN:NBNurn:nbn:hr:184:016710
Publication2023-08-31
Document URLhttps://www.mdpi.com/1422-0067/24/17/13498
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-09-01 07:42:08