prikaz prve stranice dokumenta Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency
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Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency
International Journal of Molecular Sciences, 24 (2023), 17; 13498. https://doi.org/10.3390/ijms241713498
Matišić, Vid; Brlek, Petar; Bulić, Luka; Molnar, Vilim; Dasović, Marina; Primorac, Dragan

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Matišić, V., Brlek, P., Bulić, L., Molnar, V., Dasović, M. i Primorac, D. (2023). Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency. International Journal of Molecular Sciences, 24. (17), 13498. doi: 10.3390/ijms241713498

Matišić, Vid, et al. "Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency." International Journal of Molecular Sciences, vol. 24, br. 17, 2023, str. 13498. https://doi.org/10.3390/ijms241713498

Matišić, Vid, Petar Brlek, Luka Bulić, Vilim Molnar, Marina Dasović i Dragan Primorac. "Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency." International Journal of Molecular Sciences 24, br. 17 (2023): 13498. https://doi.org/10.3390/ijms241713498

Matišić, V., et al. (2023) 'Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency', International Journal of Molecular Sciences, 24(17), str. 13498. doi: 10.3390/ijms241713498

Matišić V, Brlek P, Bulić L, Molnar V, Dasović M, Primorac D. Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency. International Journal of Molecular Sciences [Internet]. 31.08.2023. [pristupljeno 04.11.2024.];24(17):13498. doi: 10.3390/ijms241713498

V. Matišić, P. Brlek, L. Bulić, V. Molnar, M. Dasović i D. Primorac, "Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency", International Journal of Molecular Sciences, vol. 24, br. 17, str. 13498, Kolovoz 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:016710. [Citirano: 04.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:016710
Podaci o radu
Naslov (engleski)Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency
AutorVid Matišić
AutorPetar Brlek
AutorLuka Bulić
AutorVilim Molnar
AutorMarina Dasović
AutorDragan Primorac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Background: Adverse drug reactions (ADRs) are a significant cause of mortality, and pharmacogenomics (PGx) offers the potential to optimize therapeutic efficacy while minimizing ADRs. However, there is a lack of data on the Croatian population, highlighting the need for investigating the most common alleles, genotypes, and phenotypes to establish national guidelines for drug use. Methods: A single-center retrospective cross-sectional study was performed to examine the allele, genotype, and phenotype frequencies of drug-metabolizing enzymes, receptors, and other proteins in a random sample of 522 patients from Croatia using a 28-gene PGx panel. Results: Allele frequencies, genotypes, and phenotypes for the investigated genes were determined. No statistically significant differences were found between the Croatian and European populations for most analyzed genes. The most common genotypes observed in the patients resulted in normal metabolism rates. However, some genes showed higher frequencies of altered metabolism rates. Conclusions: This study provides insights into the allele, genotype, and phenotype frequencies of drug-metabolizing enzymes, receptors, and other associated proteins in the Croatian population. The findings contribute to optimizing drug use guidelines, potentially reducing ADRs, and improving therapeutic efficacy. Further research is needed to tailor population-specific interventions based on these findings and their long-term benefits.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 24, br. 17, str. 13498, 13498
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms241713498
URN:NBNurn:nbn:hr:184:016710
Datum objave publikacije2023-08-31
URL dokumentahttps://www.mdpi.com/1422-0067/24/17/13498
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-09-01 07:42:08