prikaz prve stranice dokumenta Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP
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Scientific paper - Original scientific paper
Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP
Life, 13 (2023); 2189. https://doi.org/10.3390/life13112189
Cvetko Krajinović, Lidija; Bodulić, Kristijan; Laškaj, Renata; Žibrat, Branka; Svoboda Karić, Petra; Kurolt, Ivan-Christian; Kordun, Mihaela; Topić, Antea; Čivljak, Rok; Skuhala, Tomislava; Markotić, Alemka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Cvetko Krajinović, L., Bodulić, K., Laškaj, R., Žibrat, B., Svoboda Karić, P., Kurolt, I. C. ... Markotić, A. (2023). Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP. Life, 13.. doi: 10.3390/life13112189

Cvetko Krajinović, Lidija, et al. "Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP." Life, vol. 13, 2023. https://doi.org/10.3390/life13112189

Cvetko Krajinović, Lidija, Kristijan Bodulić, Renata Laškaj, Branka Žibrat, Petra Svoboda Karić, Ivan Christian Kurolt, Mihaela Kordun, et al. "Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP." Life 13 (2023). https://doi.org/10.3390/life13112189

Cvetko Krajinović, L., et al. (2023) 'Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP', Life, 13. doi: 10.3390/life13112189

Cvetko Krajinović L, Bodulić K, Laškaj R, Žibrat B, Svoboda Karić P, Kurolt IC, and sur.. Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP. Life [Internet]. 2023 November 10 [cited 2024 November 06];13. doi: 10.3390/life13112189

L. Cvetko Krajinović, et al., "Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP", Life, vol. 13, November 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:757168. [Accessed: 06 November 2024]

Metadata
Title (english)Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP
AuthorLidija Cvetko Krajinović
AuthorKristijan Bodulić
AuthorRenata Laškaj
AuthorBranka Žibrat
AuthorPetra Svoboda Karić
AuthorIvan-Christian Kurolt
AuthorMihaela Kordun
AuthorAntea Topić
AuthorRok Čivljak
AuthorTomislava Skuhala
AuthorAlemka Markotić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
Abstract: Hemorrhagic fever with renal syndrome (HFRS) is an acute zoonotic disease caused by viruses of the Orthohantavirus genus. This syndrome is characterized by renal and cardiopulmonary implications detectable with different biomarkers. Here, we explored the role of serum and urine levels of lipocalin-2, endothelin-1 and N-terminal pro-brain natriuretic peptide (NT-proBNP) in HFRS pathology. A total of twenty-eight patients hospitalized due to a Puumala orthohantavirus infection were included, with serum and urine samples collected on patient admission (acute phase) and discharge (convalescent phase). In comparison to healthy individuals, patients exhibited significantly higher acute-phase serum and urine levels of lipocalin-2, serum levels of endothelin-1 and serum and urine levels of NT-proBNP. Patients in the convalescent phase showed a significant decrease in urine lipocalin-2, serum endothelin-1 and serum and urine NT-proBNP levels. We recorded a strong correlation between serum levels of lipocalin-2 and endothelin-1 and urine levels of lipocalin-2 with several kidney injury markers, such as serum creatinine, urea, urine white blood cell count and proteinuria. We also demonstrated an independent correlation of serum and urine lipocalin-2 levels with acute kidney injury in HFRS. All in all, our results show an involvement of NT-proBNP, lipocalin-2 and endothelin-1 in the renal and cardiac pathology of HFRS.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleLife
Numberingvol. 13, 2189
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life13112189
URN:NBNurn:nbn:hr:184:757168
Publication2023-11-10
ProjectNumber: IP-2013-11-4393
Title (croatian): Nespecifična imunost na hantaviruse
Title (english): Innate immunity to hantaviruses
Acronym: HANTA-INNATE
Leader: Alemka Markotić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: KK.011.1.01.0006
Title (croatian): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: Croatia
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-11-10 09:35:03