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Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP
Life, 13 (2023); 2189. https://doi.org/10.3390/life13112189
Cvetko Krajinović, Lidija; Bodulić, Kristijan; Laškaj, Renata; Žibrat, Branka; Svoboda Karić, Petra; Kurolt, Ivan-Christian; Kordun, Mihaela; Topić, Antea; Čivljak, Rok; Skuhala, Tomislava; Markotić, Alemka

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Cvetko Krajinović, L., Bodulić, K., Laškaj, R., Žibrat, B., Svoboda Karić, P., Kurolt, I. C. ... Markotić, A. (2023). Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP. Life, 13.. doi: 10.3390/life13112189

Cvetko Krajinović, Lidija, et al. "Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP." Life, vol. 13, 2023. https://doi.org/10.3390/life13112189

Cvetko Krajinović, Lidija, Kristijan Bodulić, Renata Laškaj, Branka Žibrat, Petra Svoboda Karić, Ivan Christian Kurolt, Mihaela Kordun, et al. "Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP." Life 13 (2023). https://doi.org/10.3390/life13112189

Cvetko Krajinović, L., et al. (2023) 'Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP', Life, 13. doi: 10.3390/life13112189

Cvetko Krajinović L, Bodulić K, Laškaj R, Žibrat B, Svoboda Karić P, Kurolt IC, i sur.. Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP. Life [Internet]. 10.11.2023. [pristupljeno 29.11.2024.];13. doi: 10.3390/life13112189

L. Cvetko Krajinović, et al., "Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP", Life, vol. 13, Studeni 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:757168. [Citirano: 29.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:757168
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Naslov (engleski)Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP
AutorLidija Cvetko Krajinović
AutorKristijan Bodulić
AutorRenata Laškaj
AutorBranka Žibrat
AutorPetra Svoboda Karić
AutorIvan-Christian Kurolt
AutorMihaela Kordun
AutorAntea Topić
AutorRok Čivljak
AutorTomislava Skuhala
AutorAlemka Markotić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zarazne bolesti)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Sažetak (engleski)
Abstract: Hemorrhagic fever with renal syndrome (HFRS) is an acute zoonotic disease caused by viruses of the Orthohantavirus genus. This syndrome is characterized by renal and cardiopulmonary implications detectable with different biomarkers. Here, we explored the role of serum and urine levels of lipocalin-2, endothelin-1 and N-terminal pro-brain natriuretic peptide (NT-proBNP) in HFRS pathology. A total of twenty-eight patients hospitalized due to a Puumala orthohantavirus infection were included, with serum and urine samples collected on patient admission (acute phase) and discharge (convalescent phase). In comparison to healthy individuals, patients exhibited significantly higher acute-phase serum and urine levels of lipocalin-2, serum levels of endothelin-1 and serum and urine levels of NT-proBNP. Patients in the convalescent phase showed a significant decrease in urine lipocalin-2, serum endothelin-1 and serum and urine NT-proBNP levels. We recorded a strong correlation between serum levels of lipocalin-2 and endothelin-1 and urine levels of lipocalin-2 with several kidney injury markers, such as serum creatinine, urea, urine white blood cell count and proteinuria. We also demonstrated an independent correlation of serum and urine lipocalin-2 levels with acute kidney injury in HFRS. All in all, our results show an involvement of NT-proBNP, lipocalin-2 and endothelin-1 in the renal and cardiac pathology of HFRS.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaLife
Brojčani podacivol. 13, 2189
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life13112189
URN:NBNurn:nbn:hr:184:757168
Datum objave publikacije2023-11-10
ProjektŠifra: IP-2013-11-4393
Naziv (hrvatski): Nespecifična imunost na hantaviruse
Naziv (engleski): Innate immunity to hantaviruses
Kratica: HANTA-INNATE
Voditelj: Alemka Markotić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: KK.011.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: ERDF
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-11-10 09:35:03