prikaz prve stranice dokumenta Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration
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Scientific paper - Original scientific paper
Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration
Diabetes Research and Clinical Practice, 207 (2024); 111056. https://doi.org/10.1016/j.diabres.2023.111056
Gašparini, Dora; Wensveen, Felix M.; Turk Wensveen, Tamara

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Gašparini, D., Wensveen, F. M. & Turk Wensveen, T. (2024). Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration. Diabetes Research and Clinical Practice, 207.. doi: 10.1016/j.diabres.2023.111056

Gašparini, Dora, et al. "Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration." Diabetes Research and Clinical Practice, vol. 207, 2024. https://doi.org/10.1016/j.diabres.2023.111056

Gašparini, Dora, Felix M. Wensveen and Tamara Turk Wensveen. "Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration." Diabetes Research and Clinical Practice 207 (2024). https://doi.org/10.1016/j.diabres.2023.111056

Gašparini, D., Wensveen, F. M. and Turk Wensveen, T. (2024) 'Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration', Diabetes Research and Clinical Practice, 207. doi: 10.1016/j.diabres.2023.111056

Gašparini D, Wensveen FM, Turk Wensveen T. Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration. Diabetes Research and Clinical Practice [Internet]. 2024 January [cited 2024 July 13];207. doi: 10.1016/j.diabres.2023.111056

D. Gašparini, F. M. Wensveen and T. Turk Wensveen, "Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration", Diabetes Research and Clinical Practice, vol. 207, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:045788. [Accessed: 13 July 2024]

Metadata
Title (english)Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration
AuthorDora Gašparini https://orcid.org/0000-0002-0503-9516
AuthorFelix M. Wensveen
AuthorTamara Turk Wensveen
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aims: Inflammageing, the age-related systemic increase of proinflammatory factors, has been linked to the development of cardiovascular disease, chronic kidney disease and cancer in the elderly. Chronic inflammation is believed to be a causative factor in the development of diabetic complications. However, exactly how type 2 diabetes impacts the inflammatory state of the immune system is incompletely characterised. Methods: Blood collection and anthropometric measurements were performed in patients with type 2 diabetes (n=49) and control subjects (n=30). The phenotype, proliferation capacity and cytokine production by cytotoxic lymphocytes were analysed using multiparametric flow cytometry. Results: Type 2 diabetes did not impact the phenotype or proliferation of the investigated cells. However, we observed a significantly increased production of tumour necrosis factor-α by CD8+ T cells and Granzyme B by natural killer cells and γδ T cells compared to controls. Hyperresponsiveness of cytotoxic blood lymphocytes did not correlate with glycaemia or body mass index, but instead was associated with older age and longer diabetes duration. Conclusions: Type 2 diabetes is associated with an increased pro-inflammatory potential of cytotoxic blood lymphocytes correlating with age and diabetes duration. Further research is necessary to explore potential benefits of diabetes medications in reverting this effect.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiabetes Research and Clinical Practice
Numberingvol. 207, 111056
p-ISSN0168-8227
DOIhttps://doi.org/10.1016/j.diabres.2023.111056
URN:NBNurn:nbn:hr:184:045788
Publication2024-01
ProjectNumber: IP-2016-06-8027
Title (croatian): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Title (english): Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency
Acronym: T-MEMORY
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-CORONA-2020-04-2045
Title (croatian): Manipuliranje imunološkom memorijom: razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja
Title (english): Memory Manipulation: Development of novel strategies to enhance the memory CD8 T-cell response against COVID-19 following vaccination
Acronym: CORONAWAI
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP-CORONA
ProjectNumber: IP-2020-02-7928
Title (croatian): Utjecaj šećerne bolesti tipa 2 i njezinog liječenja na funkciju limfocita
Acronym: DIABOLYC
Leader: Tamara Turk Wensveen
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0168822723008197
Type of resourceText
Access conditionsInstitutional access
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Created on2023-12-21 10:49:10