prikaz prve stranice dokumenta Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration
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Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration
Diabetes Research and Clinical Practice, 207 (2024); 111056. https://doi.org/10.1016/j.diabres.2023.111056
Gašparini, Dora; Wensveen, Felix M.; Turk Wensveen, Tamara

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Gašparini, D., Wensveen, F. M. i Turk Wensveen, T. (2024). Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration. Diabetes Research and Clinical Practice, 207.. doi: 10.1016/j.diabres.2023.111056

Gašparini, Dora, et al. "Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration." Diabetes Research and Clinical Practice, vol. 207, 2024. https://doi.org/10.1016/j.diabres.2023.111056

Gašparini, Dora, Felix M. Wensveen i Tamara Turk Wensveen. "Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration." Diabetes Research and Clinical Practice 207 (2024). https://doi.org/10.1016/j.diabres.2023.111056

Gašparini, D., Wensveen, F. M. i Turk Wensveen, T. (2024) 'Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration', Diabetes Research and Clinical Practice, 207. doi: 10.1016/j.diabres.2023.111056

Gašparini D, Wensveen FM, Turk Wensveen T. Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration. Diabetes Research and Clinical Practice [Internet]. 01.2024. [pristupljeno 23.05.2024.];207. doi: 10.1016/j.diabres.2023.111056

D. Gašparini, F. M. Wensveen i T. Turk Wensveen, "Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration", Diabetes Research and Clinical Practice, vol. 207, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:045788. [Citirano: 23.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:045788
Podaci o radu
Naslov (engleski)Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration
AutorDora Gašparini https://orcid.org/0000-0002-0503-9516
AutorFelix M. Wensveen
AutorTamara Turk Wensveen
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Aims: Inflammageing, the age-related systemic increase of proinflammatory factors, has been linked to the development of cardiovascular disease, chronic kidney disease and cancer in the elderly. Chronic inflammation is believed to be a causative factor in the development of diabetic complications. However, exactly how type 2 diabetes impacts the inflammatory state of the immune system is incompletely characterised. Methods: Blood collection and anthropometric measurements were performed in patients with type 2 diabetes (n=49) and control subjects (n=30). The phenotype, proliferation capacity and cytokine production by cytotoxic lymphocytes were analysed using multiparametric flow cytometry. Results: Type 2 diabetes did not impact the phenotype or proliferation of the investigated cells. However, we observed a significantly increased production of tumour necrosis factor-α by CD8+ T cells and Granzyme B by natural killer cells and γδ T cells compared to controls. Hyperresponsiveness of cytotoxic blood lymphocytes did not correlate with glycaemia or body mass index, but instead was associated with older age and longer diabetes duration. Conclusions: Type 2 diabetes is associated with an increased pro-inflammatory potential of cytotoxic blood lymphocytes correlating with age and diabetes duration. Further research is necessary to explore potential benefits of diabetes medications in reverting this effect.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDiabetes Research and Clinical Practice
Brojčani podacivol. 207, 111056
p-ISSN0168-8227
DOIhttps://doi.org/10.1016/j.diabres.2023.111056
URN:NBNurn:nbn:hr:184:045788
Datum objave publikacije2024-01
ProjektŠifra: IP-2016-06-8027
Naziv (hrvatski): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Naziv (engleski): Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency
Kratica: T-MEMORY
Voditelj: Felix Martinus Wensveen
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: IP-CORONA-2020-04-2045
Naziv (hrvatski): Manipuliranje imunološkom memorijom: razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja
Naziv (engleski): Memory Manipulation: Development of novel strategies to enhance the memory CD8 T-cell response against COVID-19 following vaccination
Kratica: CORONAWAI
Voditelj: Felix Martinus Wensveen
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP-CORONA
ProjektŠifra: IP-2020-02-7928
Naziv (hrvatski): Utjecaj šećerne bolesti tipa 2 i njezinog liječenja na funkciju limfocita
Kratica: DIABOLYC
Voditelj: Tamara Turk Wensveen
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0168822723008197
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
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Datum i vrijeme pohrane2023-12-21 10:49:10