prikaz prve stranice dokumenta Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis
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Scientific paper - Original scientific paper
Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis
Journal of Orthopaedic Research, / (2024), /; 1-8. https://doi.org/10.1002/jor.25804
Tudor, Karlo; Baranasić, Jurica; Knežević, Jelena; Šerer Vičević, Marta; Šutić, Maja; Dembić, Zlatko; Jotanović, Zdravko

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Tudor, K., Baranasić, J., Knežević, J., Šerer Vičević, M., Šutić, M., Dembić, Z. & Jotanović, Z. (2024). Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis. Journal of Orthopaedic Research, /. (/), 1-8. doi: 10.1002/jor.25804

Tudor, Karlo, et al. "Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis." Journal of Orthopaedic Research, vol. /, no. /, 2024, pp. 1-8. https://doi.org/10.1002/jor.25804

Tudor, Karlo, Jurica Baranasić, Jelena Knežević, Marta Šerer Vičević, Maja Šutić, Zlatko Dembić and Zdravko Jotanović. "Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis." Journal of Orthopaedic Research /, no. / (2024): 1-8. https://doi.org/10.1002/jor.25804

Tudor, K., et al. (2024) 'Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis', Journal of Orthopaedic Research, /(/), pp. 1-8. doi: 10.1002/jor.25804

Tudor K, Baranasić J, Knežević J, Šerer Vičević M, Šutić M, Dembić Z, and sur.. Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis. Journal of Orthopaedic Research [Internet]. 2024 February 11 [cited 2024 November 08];/(/):1-8. doi: 10.1002/jor.25804

K. Tudor, et al., "Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis", Journal of Orthopaedic Research, vol. /, no. /, pp. 1-8, February 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:873921. [Accessed: 08 November 2024]

Metadata
Title (english)Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis
AuthorKarlo Tudor
AuthorJurica Baranasić
AuthorJelena Knežević
AuthorMarta Šerer Vičević
AuthorMaja Šutić
AuthorZlatko Dembić
AuthorZdravko Jotanović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Orthopedics and Physical Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Abstract (english)
Abstract Primary osteoarthritis (POA) is a complex hereditary disease that involves the interplay between genetics and epigenetics. MicroRNA molecules play important roles in epigenetic mechanisms. MicroRNA‐146a (miR‐146a) is a negative regulator of the immune response in osteoarthritis (OA). So, variations in the miR‐146a gene could affect OA risk. The aim of this study was to investigate the relationships between single nucleotide polymorphisms (SNPs) in the miR‐146a, interleukin‐6 (IL‐6), Toll‐like receptor 10 (TLR10), and tumor necrosis factor‐alpha (TNFA) genes and the risk for development of advanced‐stage primary hip osteoarthritis (PHOA) and primary knee osteoarthritis (PKOA) in the Croatian population. A total of 609 POA patients and 656 healthy donors were genotyped for SNPs in the miR‐146a (rs2910164, G>C). Since we used same patients and controls as two studies before us, we already had information about IL‐6 (rs1800795, C>G), TLR10 (rs11096957, C>T), and TNFA (rs1800629, C>T) genotypes of our subjects. None of the differences were statistically significant comparing either allelic or genotypic frequencies of miR‐146a SNP rs2910164 (G>C) between the PHOA and PKOA patients and controls. However, we found a significant association with risk to PHOA for the combination of genotypes (stratified miR‐146a genotype with the IL‐6, and stratified miR‐146a genotype with the TNFA). In a multifactorial disease such as POA, we have shown the indirect relevance of a second modifying factor (miR‐146a), which apparently contributes to the overall risk of PHOA. There was no risk association with the PKOA, indicating that these two localities (hip and knee) might have different risk‐modifying factors.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Orthopaedic Research
Numberingvol. /, no. /, pp. 1-8, 25804
p-ISSN0736-0266
e-ISSN1554-527X
DOIhttps://doi.org/10.1002/jor.25804
URN:NBNurn:nbn:hr:184:873921
Publication2024-02-11
Document URLhttps://onlinelibrary.wiley.com/doi/10.1002/jor.25804
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2024-02-28 11:44:20