prikaz prve stranice dokumenta Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis
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Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis
Journal of Orthopaedic Research, / (2024), /; 1-8. https://doi.org/10.1002/jor.25804
Tudor, Karlo; Baranasić, Jurica; Knežević, Jelena; Šerer Vičević, Marta; Šutić, Maja; Dembić, Zlatko; Jotanović, Zdravko

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Tudor, K., Baranasić, J., Knežević, J., Šerer Vičević, M., Šutić, M., Dembić, Z. i Jotanović, Z. (2024). Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis. Journal of Orthopaedic Research, /. (/), 1-8. doi: 10.1002/jor.25804

Tudor, Karlo, et al. "Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis." Journal of Orthopaedic Research, vol. /, br. /, 2024, str. 1-8. https://doi.org/10.1002/jor.25804

Tudor, Karlo, Jurica Baranasić, Jelena Knežević, Marta Šerer Vičević, Maja Šutić, Zlatko Dembić i Zdravko Jotanović. "Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis." Journal of Orthopaedic Research /, br. / (2024): 1-8. https://doi.org/10.1002/jor.25804

Tudor, K., et al. (2024) 'Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis', Journal of Orthopaedic Research, /(/), str. 1-8. doi: 10.1002/jor.25804

Tudor K, Baranasić J, Knežević J, Šerer Vičević M, Šutić M, Dembić Z, i sur.. Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis. Journal of Orthopaedic Research [Internet]. 11.02.2024. [pristupljeno 07.11.2024.];/(/):1-8. doi: 10.1002/jor.25804

K. Tudor, et al., "Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis", Journal of Orthopaedic Research, vol. /, br. /, str. 1-8, Veljača 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:873921. [Citirano: 07.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:873921
Podaci o radu
Naslov (engleski)Indirect influence of microRNA‐146a on the association of IL‐6 and TNF‐α genetic polymorphisms with the increased risk of hip osteoarthritis
AutorKarlo Tudor
AutorJurica Baranasić
AutorJelena Knežević
AutorMarta Šerer Vičević
AutorMaja Šutić
AutorZlatko Dembić
AutorZdravko Jotanović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ortopediju i fizikalnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ortopedija
Sažetak (engleski)
Abstract Primary osteoarthritis (POA) is a complex hereditary disease that involves the interplay between genetics and epigenetics. MicroRNA molecules play important roles in epigenetic mechanisms. MicroRNA‐146a (miR‐146a) is a negative regulator of the immune response in osteoarthritis (OA). So, variations in the miR‐146a gene could affect OA risk. The aim of this study was to investigate the relationships between single nucleotide polymorphisms (SNPs) in the miR‐146a, interleukin‐6 (IL‐6), Toll‐like receptor 10 (TLR10), and tumor necrosis factor‐alpha (TNFA) genes and the risk for development of advanced‐stage primary hip osteoarthritis (PHOA) and primary knee osteoarthritis (PKOA) in the Croatian population. A total of 609 POA patients and 656 healthy donors were genotyped for SNPs in the miR‐146a (rs2910164, G>C). Since we used same patients and controls as two studies before us, we already had information about IL‐6 (rs1800795, C>G), TLR10 (rs11096957, C>T), and TNFA (rs1800629, C>T) genotypes of our subjects. None of the differences were statistically significant comparing either allelic or genotypic frequencies of miR‐146a SNP rs2910164 (G>C) between the PHOA and PKOA patients and controls. However, we found a significant association with risk to PHOA for the combination of genotypes (stratified miR‐146a genotype with the IL‐6, and stratified miR‐146a genotype with the TNFA). In a multifactorial disease such as POA, we have shown the indirect relevance of a second modifying factor (miR‐146a), which apparently contributes to the overall risk of PHOA. There was no risk association with the PKOA, indicating that these two localities (hip and knee) might have different risk‐modifying factors.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Orthopaedic Research
Brojčani podacivol. /, br. /, str. 1-8, 25804
p-ISSN0736-0266
e-ISSN1554-527X
DOIhttps://doi.org/10.1002/jor.25804
URN:NBNurn:nbn:hr:184:873921
Datum objave publikacije2024-02-11
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1002/jor.25804
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-02-28 11:44:20